Expression Pattern and Prognostic Significance of Gene in Adult Acute Myeloid Leukemia Patients with Normal Karyotype.

According to current criteria, patients with acute myeloid leukemia with normal karyotype (AML-NK) are classified as intermediate risk patients. There is a constant need for additional molecular markers that will help in substratification into more precise prognostic groups. One of the potential new markers is Ecotropic viral integration 1 site () transcriptional factor, whose expression is dissregulated in abnormal hematopoietic process. The purpose of this study was to examine gene expression in 104 adult AML-NK patients and on 10 healthy bone marrow donors using real-time polymerase chain reaction method, and to evaluate association between expression level and other molecular and clinical features, and to examine its potential influence on the prognosis of the disease. Overexpression of gene ( status) was present in 17% of patients. Increased expression was predominantly found in patients with lower WBC count (= 0.003) and lower bone marrow blast percentage (= 0.005). patients had lower expression level (= 0.041), and were negative for - and mutations (= 0.036 and = 0.003). Patients with status had higher complete remission rate (= 0.047), but expression didn't influence overall and disease free survival. expression status alone, cannot be used as a new marker for more precise substratification of AML-NK patients. Further investigations conducted on larger number of patients may indicate how expression could influence the prognosis and outcome of AML-NK patients, by itself, or in the context of other molecular and clinical parameters.