• Unlike venous thromboembolism, no data are available on arterial thrombosis in SARS-CoV2 infected patients. • We observed severe arterial thrombotic complications despite the use of antiplatelet or anticoagulant therapy. • We described five irreversible lower limb ischemia and two thoracic aortic free floating thrombi. • Further studies are needed to evaluate the necessity of therapeutic anticoagulation in COVID-19 patients.

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