AI Article Synopsis
Article Abstract
The assessment of potentially sensitive populations is an important application of risk assessment. To address the concern for age-related sensitivity to pyrethroid insecticides, life-stage physiologically based pharmacokinetic (PBPK) modeling supported by in vitro to in vivo extrapolation was conducted to predict age-dependent changes in target tissue exposure to 8 pyrethroids. The purpose of this age-dependent dosimetry was to calculate a Data-derived Extrapolation Factor (DDEF) to address age-related pharmacokinetic differences for pyrethroids in humans. We developed a generic human PBPK model for pyrethroids based on our previously published rat model that was developed with in vivo rat data. The results demonstrated that the age-related differences in internal exposure to pyrethroids in the brain are largely determined by the differences in metabolic capacity and in physiology for pyrethroids between children and adults. The most important conclusion from our research is that, given an identical external exposure, the internal (target tissue) concentration is equal or lower in children than in adults in response to the same level of exposure to a pyrethroid. Our results show that, based on the use of the life-stage PBPK models with 8 pyrethroids, DDEF values are essentially close to 1, resulting in a DDEF for age-related pharmacokinetic differences of 1. For risk assessment purposes, this indicates that no additional adjustment factor is necessary to account for age-related pharmacokinetic differences for these pyrethroids.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416317 | PMC |
| http://dx.doi.org/10.1093/toxsci/kfaa070 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mortality reduction with 23-valent pneumococcal polysaccharide vaccine: a systematic review and meta-analysis.
Pneumonia (Nathan)
December 2024
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India.
Background: Pneumococcal disease, caused by Streptococcus pneumoniae, imposes a significant global health burden, particularly affecting vulnerable groups such as the elderly and immunocompromised. The 23-valent pneumococcal polysaccharide vaccine (PPV23) is designed to protect against 23 serotypes of Streptococcus pneumoniae. However, there is ongoing debate about its effectiveness in reducing all-cause mortality.
View Article and Find Full Text PDFPredicting higher risk factors for COVID-19 short-term reinfection in patients with rheumatic diseases: a modeling study based on XGBoost algorithm.
J Transl Med
December 2024
Department of Rheumatology and Immunology, Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Tianhe District, Guangzhou, China.
Background: Corona virus disease 2019 (COVID-19) reinfection, particularly short-term reinfection, poses challenges to the management of rheumatic diseases and may increase adverse clinical outcomes. This study aims to develop machine learning models to predict and identify the risk of short-term COVID-19 reinfection in patients with rheumatic diseases.
Methods: We developed four prediction models using explainable machine learning to assess the risk of short-term COVID-19 reinfection in 543 patients with rheumatic diseases.
Clinical significance of the combined systemic immune-inflammatory index and prognostic nutritional index in predicting the prognosis of patients with extensive-stage small-cell lung cancer receiving immune-combination chemotherapy.
BMC Cancer
December 2024
Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150000, China.
Background: The therapeutic efficacy and prognosis of various tumors can be assessed using the systemic immune-inflammatory index (SII) and prognostic nutritional index (PNI). Despite their potential, no studies have investigated the prognostic value of the combined SII-PNI score for outcomes in patients with extensive small cell lung cancer (ES-SCLC) treated with chemotherapy and immune checkpoint inhibitors (ICIs).
Materials And Methods: Our study retrospectively examined 213 ES-SCLC patients treated with chemotherapy and ICIs across two institutions.
Socioeconomic and geographical inequalities in polio immunisation coverage among two-year-olds in Sierra Leone, 2008-2019.
BMC Infect Dis
December 2024
Department of Environmental Health, School of Community Health Sciences, Njala University, PMB, Freetown, Sierra Leone.
Background: Polio, a debeilitating and potentially life-threatening disease, continues to pose a risk to young children globally. While vaccination offers a powerful shield, its reach is not always equal. This study explores socioeconomic and geographical inequalities in polio immunisation coverage among two-year-olds in Sierra Leone between 2008 and 2019.
View Article and Find Full Text PDFTrajectory of breastfeeding among Chinese women and risk prediction models based on machine learning: a cohort study.
BMC Pregnancy Childbirth
December 2024
Department of Obstetric Nursing, West China Second University Hospital, Sichuan University, No. 1416, Chenglonglu Avenue, Chengdu, Sichuan, Jinjiang District, 610066, China.
Background: Breastfeeding is the optimal source of nutrition for infants and young children, essential for their healthy growth and development. However, a gap in cohort studies tracking breastfeeding up to six months postpartum may lead caregivers to miss critical intervention opportunities.
Methods: This study conducted a three-wave prospective cohort analysis to examine maternal breastfeeding trajectories within the first six months postpartum and to develop risk prediction models for each period using advanced machine learning algorithms.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!