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The Microbiota-Gut-Brain Axis and Neurological Disorders: A Comprehensive Review.
Life (Basel)
September 2024
Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
Article Synopsis
- * Research over the past 20 years shows that the MGBA significantly affects various neurological diseases, including Alzheimer's, autism, ADHD, and others.
- * Understanding the MGBA can lead to new microbial-based treatments for these neurological conditions, as factors like diet, exercise, and medication can impact this communication pathway.
Objective: The aim is to determine the neuropsychological peculiarities of cognitive and communicative activities in adults with the extrapyramidal system disorders.
Patients And Methods: Materials and methods: The research was conducted during 2018-2021, during which a retrospective analysis of medical treatment records of the patients with extrapyramidal disorders of various etiologies was performed. The research involved 137 adult patients with extrapyramidal disorders: 93 persons with Parkinson's disease, 36 people with manganese encephalopathy, 5 persons with progressive supranuclear palsy and 3 people with Wilson-Konovalov disease.
The first experience of non-interferon therapy of HCV infection in patients with Wilson-Konovalov's disease.
Ter Arkh
November 2018
Faculty of Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia.
In the article we present three clinical observations demonstrating that HCV infection in patients with remission of Wilson disease causes an recrudescence of the disease, in one of the observations - decompensation of liver cirrhosis. In this study we first describe on the successful treatment of HCV infection with direct antiviral drugs in patients with Wilson disease. Establishment of all factors of liver damage and successful treatment (elimination of the virus, adequate lifelong medical treatment) allow to expect a favorable prognosis in patients with a combination of Wilson disease and HCV infection.
View Article and Find Full Text PDFWilson-Konovalov's disease (DWK) is a polysyndrome hereditary disease associated with excessive accumulation of copper due to the delay in its removal from the body. The condition of the reproductive system in patients with DWK is not well understood. It is proved that copper is a microelement necessary for the synthesis of estrogens, the secretion of prostaglandins in the endometrium.
View Article and Find Full Text PDFWilson-Konovalov's disease is a rare genetic pathology of copper metabolism that in the first place affects liver and CNS. Due to autosomal-recessive inheritance of this condition, it most frequently occurs in sibs. We report a case of Wilson-Konovalov's disease in two sisters differing in its clinical course: severe abdominal variant in the younger sister and largely neurologic form in the elder one.
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