[Leptin, adiponectin, lipodystrophic and severe insulin resistance syndromes].

Ann Biol Clin (Paris)

Sorbonne Université, Inserm UMR_S 938, Centre de recherche Saint-Antoine, Institut hospitalo-universitaire de cardio-métabolisme et nutrition (ICAN), Paris, France, Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine, Centre national de référence des pathologies rares de l'insulino-sécrétion et de l'insulino-sensibilité (PRISIS), Service d'endocrinologie, diabétologie et endocrinologie de la reproduction, Paris, France, Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine, Laboratoire commun de biologie et génétique moléculaires, Paris, France.

Published: June 2020

Leptin and adiponectin are two adipokines currently used as biomarkers for diagnostic orientation and phenotyping in syndromes of lipodystrophy and severe insulin resistance. The level of these biomarkers also has an impact on the therapeutic management of the patients. These aspects, as well as our experience as a reference center, are described in this brief overview.

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http://dx.doi.org/10.1684/abc.2020.1551DOI Listing

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