Aim: To compare the efficacy and safety between laser therapy and anti-vascular endothelial growth factor (VEGF) agents intravitreal injection monotherapy in type-1 retinopathy of prematurity (ROP) and aggressive posterior retinopathy of prematurity (APROP).
Methods: A systematic literature search was performed in PubMed, Cochrane Library, and Embase for original comparable studies. We included studies that compare laser therapy and intravitreal injections of anti-VEGF agents monotherapy in ROP regardless of languages and publication types.
Results: Complication incidence was significantly higher in laser therapy group (OR: 0.38; 95%CI: 0.19-0.75; =0.005). Spherical equivalent (SE) was higher in laser therapy [weighted mean difference (WMD): 2.40, 95%CI: 0.88-3.93; =0.002]. The time between treatment and retreatment was longer in laser therapy group (WMD: 8.45, 95%CI: 5.35-11.55; <0.00001). Recurrence incidence (OR: 0.97; 95%CI: 0.45-2.09; =0.93) and retreatment incidence (OR: 1.24; 95%CI: 0.56-2.73; =0.59) were similar in two approaches. Subgroup analysis between type-1 ROP and APROP was not significant except SE reported in the included studies (<0.0001).
Conclusion: This Meta-analysis outcome indicates anti-VEGF agents are as effective as laser treatment, and safer than laser in type-1 ROP and APROP. The degree of myopia in APROP is higher than type-1 ROP. More randomized controlled trials in large sample size should be conducted in the future.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201341 | PMC |
| http://dx.doi.org/10.18240/ijo.2020.05.17 | DOI Listing |
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