AI Article Synopsis
- The study explores the potential of Dipsaci Radix (DR) as a treatment for lung cancer, focusing on its molecular mechanisms and active compounds.
- DR contains six active compounds, such as gentisin and sitosterol, that interact with 254 target genes, with SRC, AKT1, and GRB2 identified as key players.
- The findings suggest DR can combat lung cancer by targeting multiple pathways, highlighting its significance in traditional Chinese medicine for anticancer therapy.
Article Abstract
Objective: Dipsaci Radix (DR) has been used to treat fracture and osteoporosis. Recent reports have shown that myeloid cells from bone marrow can promote the proliferation of lung cancer. However, the action and mechanism of DR has not been well defined in lung cancer. The aim of the present study was to define molecular mechanisms of DR as a potential therapeutic approach to treat lung cancer.
Methods: Active compounds of DR with oral bioavailability ≥30% and drug-likeness index ≥0.18 were obtained from the traditional Chinese medicine systems pharmacology database and analysis platform. The potential target genes of the active compounds and bone were identified by PharmMapper and GeneCards, respectively. The compound-target network and protein-protein interaction network were built by Cytoscape software and Search Tool for the Retrieval of Interacting Genes webserver, respectively. GO analysis and pathway enrichment analysis were performed using software.
Results: Our study demonstrated that DR had 6 active compounds, including gentisin, sitosterol, Sylvestroside III, 3,5-Di-O-caffeoylquinic acid, cauloside A, and japonine. There were 254 target genes related to these active compounds as well as to bone. SRC, AKT1, and GRB2 were the top 3 hub genes. Metabolisms and signaling pathways associated with these hub genes were significantly enriched.
Conclusions: This study indicated that DR could exhibit the anti-lung cancer effect by affecting multiple targets and multiple pathways. It reflects the traditional Chinese medicine characterized by multicomponents and multitargets. DR could be considered as a candidate for clinical anticancer therapy by regulating bone physiological functions.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204368 | PMC |
| http://dx.doi.org/10.1155/2020/7424061 | DOI Listing |
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