Orthopaedic metallic implant's long-term success strongly depends upon the two main factors: osseointegration and antibacterial character. Bioceramic (hydroxyapatite and hopeite) coatings have been proven effective for getting strong osseointegration and antibacterial character. However, deterioration of bioceramic coatings during the implantation period can adversely affect its overall biological performance. To conquer this issue, this research work recommends an innovative process route of laser rapid manufacturing for depositing bioceramic (hydroxyapatite and hopeite) coatings with metallurgical bonding. Microstructure, phase composition, antibacterial efficacy and bioactivity were evaluated using scanning electron microscopy, X-ray diffraction, fluorescence-activated cell sorting technique and simulated body fluid immersion test. The promising results obtained from these characterizations and testing establish the new process route laser rapid manufacturing as an effective alternative to deposit multifunctional bioceramic (hydroxyapatite and hopeite) coatings on metallic prosthetic-orthopaedic implants.
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http://dx.doi.org/10.1177/0954411920917851 | DOI Listing |
Front Chem
September 2024
Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
Int J Biol Macromol
October 2024
Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef, 65211, Egypt; Materials Technologies and their Applications Lab, Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef City, Egypt. Electronic address:
The uncontrolled administration of the cisplatin drug (CPTN) resulted in numerous drawbacks. Therefore, effective, affordable, and biocompatible delivery systems were suggested to regulate the loading, release, and therapeutic effect of CPTN. Zinc phosphate/hydroxyapatite hybrid form (ZP/HP) and core-shell nano-rod morphology, as well as its functionalized derivative with cellulose (CF@ZP/HP), were synthesized by the facile dissolution precipitation method followed by mixing with cellulose fibers, respectively.
View Article and Find Full Text PDFInt J Biol Macromol
January 2024
Materials Technologies and their Applications Lab, Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt; Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef 65211, Egypt. Electronic address:
An advanced form of zinc phosphate/hydroxyapatite nanorods with a core-shell structure (ZPh/HPA) was made and then hybridized with chitosan polymeric chains to make a safe biocomposite (CH@ZPh/HPA) that improves the delivery structure of traditional oxaliplatin (OXPN) chemotherapy during the treatment of colorectal cancer cells. The qualifications of CH@ZPh/HPA in comparison with ZPh/HPA as a carrier for OXPN were followed based on loading, release, and cytotoxicity. CH@ZPh/HPA composite exhibits a notably higher OXPN loading capacity (321.
View Article and Find Full Text PDFProc Inst Mech Eng H
April 2023
Department of Production and Industrial Engineering, National Institute of Technology, Jamshedpur, Jharkhand, India.
Magnesium (Mg) shows excellent potential for orthopedic implant applications owing to its equivalent mechanical properties compared to cortical bone and its biocompatibility. However, the rapid degradation rate of magnesium and its alloys in the physiological environment results in losing their mechanical integrity before complete bone healing. In light of this, friction stir processing (FSP), a solid-state process, is used to fabricate Hopeite (Zn(PO).
View Article and Find Full Text PDFProc Inst Mech Eng H
July 2020
Mechanical Engineering Department, Motilal Nehru National Institute of Technology Allahabad, Prayagraj, India.
Orthopaedic metallic implant's long-term success strongly depends upon the two main factors: osseointegration and antibacterial character. Bioceramic (hydroxyapatite and hopeite) coatings have been proven effective for getting strong osseointegration and antibacterial character. However, deterioration of bioceramic coatings during the implantation period can adversely affect its overall biological performance.
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