Death rattle occurs during the last days of life, and relatives of those afflicted frequently report that it is very distressful. However, there is no effective treatment for it. The purpose of this study was to investigate the perceptions of Japanese palliative care physicians in clinical practice in Japan. We conducted a nationwide survey of 268 physicians via an anonymous, self-report questionnaire. We assessed pharmacological and non-pharmacological management and anticholinergic agent choice. One hundred eighty-nine physicians (70.5%) returned the questionnaires. Fifty-five participants (29.1%) treating patients with Type-1 (real death rattle) and 36 participants (19%) treating patients with Type-2 (pseudo-death rattle) death rattle reported that they would frequently administer an anticholinergic agent. One-fourth would administer scopolamine butylbromide or scopolamine hydrobromide. In conclusion, more Japanese palliative care physicians thought that anticholinergic agents might be effective for treating Type-1 death rattle rather than Type-2. Further clinical trials of these agents are needed.
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http://dx.doi.org/10.1093/jjco/hyaa044 | DOI Listing |
J Pain Symptom Manage
February 2025
Division of Palliative Medicine (P.W.), Department of Medicine, Washington University in St. Louis, St Louis, Missouri.
Context: Research has documented common respiratory changes at the end of life for hospice patients. Some studies have noted these symptoms as distressing and challenging for families, and as a potential reason for emergency room visits and hospice benefit revocation. However, the experiences and emotions of family members regarding these respiratory changes in the final days, particularly when they are alone in a home setting, are not well documented.
View Article and Find Full Text PDFPalliat Med
December 2024
Department of Public Health and Primary Care, Gerontology and Geriatrics, KU Leuven, Leuven, Belgium.
Background: Evidence based guidelines for treatment of physical symptoms during the last days of life in older people are not available.
Aim: We wanted to synthesize the existing evidence on the pharmacological treatment of pain, dyspnea, death rattle, fever, nausea, and vomiting during the last days of life in older people to develop recommendations that can help guide clinical practice.
Design: A systematic review was conducted (PROSPERO #CRD42023406100) and reported in accordance with PRISMA guidelines.
Front Plant Sci
August 2024
IRTA, Postharvest Programme, Edifici Fruitcentre, Parc Agrobiotech Lleida, Lleida, Catalonia, Spain.
Introduction: Brown rot is the most important fungal disease affecting stone fruit and it is mainly caused by , and . spp. are necrotrophic plant pathogens with the ability to induce plant cell death by the secretion of different phytotoxic molecules, including proteins or metabolites that are collectively referred to as necrotrophic effectors (NEs).
View Article and Find Full Text PDFJ Pain Symptom Manage
September 2024
Department of Palliative Medicine (T.Y.), Kobe University Graduate School of Medicine, Kobe, Japan.
Support Care Cancer
June 2024
Surrey Clinical Trials Unit, University of Surrey, Guildford, UK.
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