Synthesis of New Piperazine Substituted Chalcone Sulphonamides as Antibacterial Agents.

Background: Infection is a global threat to human health, and there is an urgent need to develop new effective antibacterial drugs to treat bacterial infections.

Objective: To study the antibacterial activity of piperazine substituted chalcone sulphonamides.

Materials And Methods: A series of novel piperazine substituted chalcone sulphonamides have been prepared, and in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli strains were evaluated.

Results: The results showed that derivatives 6a, 6c and 6h displayed good antibacterial activity against Bacillus subtilis with MIC values of 4.0-8.0 mg/mL.

Conclusion: Piperazine substituted chalcone sulphonamides may be used as potential antibacterial agents.