AI Article Synopsis
- Spontaneous regression (SR) in colorectal cancer (CRC) is rare, and its mechanisms are not well understood, with this report detailing three unique cases from two institutions.
- All cases exhibited similar endoscopic features, being superficial lesions with a central depression, specifically located in the ascending colon.
- Biopsy specimens indicated a deficiency in DNA mismatch repair proteins, suggesting these were mismatch repair-deficient (dMMR) CRCs, potentially linking the dMMR phenotype to enhanced immune responses that may facilitate spontaneous regression.
Article Abstract
Spontaneous regression (SR) has been reported in various malignant tumors. However, SR in colorectal cancer (CRC) is particularly rare and the mechanism remains unclear. We here report three cases of CRCs displaying SR, which were experienced at two institutions. Intriguingly, all of these cases displayed the common endoscopic characteristics; superficial elevated lesion accompanied by a central depression (0-IIa + IIc, in the Paris classification), with a nonpolypoid growth, located in the ascending colon. Furthermore, immunohistology of biopsy specimens revealed the lack of DNA mismatch repair proteins within the CRC lesions, suggesting that these were mismatch repair-deficient (dMMR) CRCs. One of the major features of dMMR cancers is an increase in the number of tumor-infiltrating lymphocytes. Thus, the dMMR phenotype might be associated with SR of CRCs through the activation of anti-tumor host immune responses.
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| http://dx.doi.org/10.1111/den.13723 | DOI Listing |
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