In present work, temperature-responsive flurbiprofen (FLU) containing chitosan/hydroxypropyl cellulose (CS/HPC) blend nanospheres were prepared using emulsion method. The structures of blend nanospheres were characterized by ATR-FTIR, XRD, SEM, DSC/TGA, zeta potential and particle size analyses. Their lower critical solution temperatures (LCST) were determined and found to be 42 °C. In vitro release studies were performed in gastrointestinal-tract simulated conditions at 30 °C, 37 °C and 44 °C. As the medium temperature was increased, the release of FLU decreased, indicating that blend nanospheres had temperature-responsive feature. The FLU release demonstrated that release profiles depend upon CS/HPC ratio, amount of FLU present in the nanospheres and percentage of cross-linker used. Moreover, the cytotoxicity tests were performed via MTT method and it was observed CS/HPC nanospheres were biocompatible. Based on the in vitro release profile and cytotoxicity studies, the fabricated CS/HPC blend nanospheres could be a promising candidate as a temperature-responsive nano-carrier for controlled drug release.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijbiomac.2020.05.071 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
3D-Printed Plasmonic Nanocomposites: VAT Photopolymerization for Photothermal-Controlled Drug Release.
Pharmaceuticals (Basel)
October 2024
Department of Pharmacological and Toxicological Chemistry, University of Chile, Santos Dumont 964, Santiago 8380494, Chile.
Background: Gold nanoparticles can generate heat upon exposure to radiation due to their plasmonic properties, which depend on particle size and shape. This enables precise control over the release of active substances from polymeric pharmaceutical formulations, minimizing side effects and premature release. The technology of 3D printing, especially vat photopolymerization, is valuable for integrating nanoparticles into complex formulations.
View Article and Find Full Text PDFOn the Use of Reflection Polarized Optical Microscopy for Rapid Comparison of Crystallinity and Phase Segregation of P3HT:PCBM Thin Films.
Macromol Rapid Commun
December 2024
Physical Sciences and Engineering Division (PSE), KAUST Solar Center (KSC), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Rapid, nondestructive characterization techniques for evaluating the degree of crystallinity and phase segregation of organic semiconductor blend thin films are highly desired for in-line, automated optoelectronic device fabrication facilities. Here, it is demonstrated that reflection polarized optical microscopy (POM), a simple technique capable of imaging local anisotropy of materials, is capable of determining the relative degree of crystallinity and phase segregation of thin films of polymer:fullerene blends. While previous works on POM of organic semiconductors have largely employed the transmission geometry, it is demonstrated that reflection POM provides 3× greater contrast.
View Article and Find Full Text PDFTailoring ZnS nanostructures through precipitation-cum-hydrothermal synthesis for enhanced wastewater purification and antibacterial treatment.
Environ Res
October 2024
Laboratory of Advanced Materials and Interfaces (LIMA), University of Monastir, Faculty of Science of Monastir, Avenue of Environment, 5000, Monastir, Tunisia.
This study presents a novel blend of synthesis techniques for shape-controlled ZnS nanoparticles. Zinc sulfide (ZnS) nanoparticles with distinct morphologies cauliflower-like microstructures (∼4.5 μm) and uniform nanospheres (200-700 nm) were synthesized through an innovative blend of precipitation and hydrothermal techniques.
View Article and Find Full Text PDFWide Bandgap Polymer Donors Based on Succinimide-Substituted Thiophene for Nonfullerene Organic Solar Cells.
Macromol Rapid Commun
September 2024
Department of Chemical Engineering and Waterloo Institute for Nanotechnology (WIN), University of Waterloo, 200 University Ave West, Waterloo, N2L 3G1, Canada.
Article Synopsis
- The introduction of nonfullerene acceptors (NFAs) has significantly enhanced the efficiency of organic solar cells (OSCs), leading to an urgent need for better NFAs and compatible polymer donors.
- This study presents a new electron-withdrawing building block called succinimide-substituted thiophene (TS), which is used to synthesize three wide bandgap polymer donors that pair well with the NFA Y6 for effective sunlight absorption.
- Among the synthesized polymers, PBDTF-TSBT-C16 stands out with the highest power conversion efficiency of 13.21%, thanks to its optimal energy levels and hole mobility, showcasing the potential of TS in advancing OSC technology.
An inorganic-blended p-type semiconductor with robust electrical and mechanical properties.
Nat Commun
May 2024
Department of Materials Science and Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong SAR.
Inorganic semiconductors typically have limited p-type behavior due to the scarcity of holes and the localized valence band maximum, hindering the progress of complementary devices and circuits. In this work, we propose an inorganic blending strategy to activate the hole-transporting character in an inorganic semiconductor compound, namely tellurium-selenium-oxygen (TeSeO). By rationally combining intrinsic p-type semimetal, semiconductor, and wide-bandgap semiconductor into a single compound, the TeSeO system displays tunable bandgaps ranging from 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!