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Interaction Analysis between Cationic Lipid and Oligonucleotide with a Lipid Membrane-Immobilized Monolith Silica Column: A High-Performance Liquid Chromatography Approach.
Langmuir
January 2025
Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka 560-8531, Japan.
Understanding the interactions between lipid membranes and nucleotide drugs is crucial for nucleic acid therapy. Although several methods have been employed to evaluate nucleotide-lipid membrane interactions, these interactions can be complex; this complexity arises from how external factors, such as ionic strength or temperature, influence the lipid membrane's overall properties. In this study, we prepared a lipid membrane-immobilized monolithic silica (LMiMS) column for high-performance liquid chromatography (HPLC) analysis to understand interactions between the lipid membrane and nucleic acid.
View Article and Find Full Text PDFMid-infrared spectra of dried and roasted cocoa ( L.): A dataset for machine learning-based classification of cocoa varieties and prediction of theobromine and caffeine content.
Data Brief
February 2025
Centro Surcolombiano de Investigación en Café (CESURCAFÉ), Departamento de Ingeniería Agrícola, Universidad Surcolombiana, Neiva-Huila 410001, Colombia.
This paper presents a comprehensive dataset of mid-infrared spectra for dried and roasted cocoa beans ( L.), along with their corresponding theobromine and caffeine content. Infrared data were acquired using Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy, while High-Performance Liquid Chromatography (HPLC) was employed to accurately quantify theobromine and caffeine in the dried cocoa beans.
View Article and Find Full Text PDFThe effects of clinical and pharmacological factors on the ratio of clozapine to norclozapine in psychiatric patients.
Front Pharmacol
January 2025
Department of Psychiatry, Medical University of Warsaw, Warsaw, Poland.
Background: Due to its exceptional effectiveness, clozapine (CLO), whose metabolite is norclozapine (NCLO), is a drug of choice in the management of treatment-resistant schizophrenia. The purpose of this study was to assess the factors modifying the CLO/NCLO ratio (CNR).
Methods: A total of 446 blood samples (233 of which were drawn from females and 213 from males, aged from 18 to 77 years) were analyzed in this study.
Electroresponsive Thiol-Yne Click-Hydrogels for Insulin Smart Delivery: Tackling Sustained Release and Leakage Control.
ACS Appl Polym Mater
July 2024
Departament d'Enginyeria Química, Campus Diagonal Besòs (EEBE), Universitat Politècnica de Catalunya Barcelona Tech, Av. Eduard Maristany 10-14, Barcelona 08019, Spain.
Diabetes is a metabolic disorder caused by the body's inability to produce or use insulin. Considering the figures projected by the World Health Organization, research on insulin therapy is crucial. Hence, we present a soft biointerface based on a thiol-yne poly(ethylene glycol) (PEG) click-hydrogel as an advanced treatment option to administrate insulin.
View Article and Find Full Text PDFToward Green and Sustainable Zinc-Ion Batteries: The Potential of Natural Solvent-Based Electrolytes.
Small
January 2025
Department of Chemistry, Eskisehir Osmangazi University (ESOGU), Eskisehir, 26040, Turkey.
Zinc-ion batteries (ZIBs) are emerged as a promising alternative for sustainable energy storage, offering advantages such as safety, low cost, and environmental friendliness. However, conventional aqueous electrolytes in ZIBs face significant challenges, including hydrogen evolution reaction (HER) and zinc dendrite formation, compromising their cycling stability and safety. These limitations necessitate innovative electrolyte solutions to enhance ZIB performance while maintaining sustainability.
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