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Liver transplants from paracetamol overdose: is it time to rethink OTC availability?
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Clinical Pharmacy Service, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Palermo, Italy
Rethinking primary particulate matter: Integrating filterable and condensable particulate matter in measurement and analysis.
Sci Total Environ
January 2025
Particle Pollution Research and Management Center, Incheon 21999, Republic of Korea; Department of Environmental Engineering, Inha University, Incheon 22212, Republic of Korea. Electronic address:
The current definition of primary particulate matter (PM) encompasses filterable PM (FPM) and condensable PM (CPM), which are evaluated using two distinct conventional measurement methods: cooling and dilution. While the cooling method exclusively considers the homogenous formation of CPM, the dilution method, closer to real-world conditions, neglects FPM characterization. To overcome this limitation, we propose a doubled-dilution system that enables the parallel characterization of both FPM and primary PM without diverting FPM from the CPM formation pathway.
View Article and Find Full Text PDFBeyond the Illusion of Controlled Environments: How to Embrace Ecological Pertinence in Research?
Eur J Neurosci
January 2025
Department of Biology, Concordia University, Montreal, QC, Canada.
Through the lens of preclinical research on substance use disorders (SUD), I propose a reflection aimed at re-evaluating animal models in neuroscience, with a focus on ecological relevance. While rodent models have provided valuable insights into the neurobiology of SUD, the field currently faces a validation crisis, with findings often failing to translate into effective human treatments. Originally designed to address the lack of reproducibility in animal studies, the current global gold standard of rigorous standardization has led to increasingly controlled environments.
View Article and Find Full Text PDFOvercoming Challenges in the Commercialization of Biopolymers: From Research to Applications-A Review.
Polymers (Basel)
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Aachen-Maastricht Institute for Biobased Materials (AMIBM), Faculty of Science and Engineering, Maastricht University, Brightlands Chemelot Campus, Urmonderbaan 22, 6167 RD Geleen, The Netherlands.
Biopolymers are promising sustainable alternatives to petrochemical polymers, but the recent increase in published research articles has not translated into marketable products. Here, we discuss barriers to market entry by exploring application-specific, ecological, and economic aspects, such as the utilization of biodegradable polymers to mitigate the accumulation of microplastics. We summarize previous studies revealing how fiber surface properties and the dwell time during fiber spinning affect degradability.
View Article and Find Full Text PDFPopulation Studies and Molecular Mechanisms of Human Radioadaptive Capabilities: Is It Time to Rethink Radiation Safety Standards?
Int J Mol Sci
December 2024
Department of Regenerative Medicine, National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
The evolution of man on Earth took place under conditions of constant exposure to background ionizing radiation (IR). From this point of view, it would be reasonable to hypothesize the existence of adaptive mechanisms that enable the human organism to safely interact with IR at levels approximating long-term natural background levels. In some situations, the successful operation of molecular mechanisms of protection against IR is observed at values significantly exceeding the natural background level, for example, in cancer cells.
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