AI Article Synopsis
- The study aimed to improve the stability and release of curcumin in liposomes by replacing some soybean phospholipid (SPC) with hydrogenated soybean phospholipid (HSPC).
- It was found that a 5:5 SPC/HSPC ratio enhanced vesicle size, encapsulation efficiency, and resistance to alkali, despite a slight decrease in centrifugal stability.
- The Cur-LP at this ratio demonstrated optimal performance in terms of stability and sustained-release in simulated digestion conditions, suggesting HSPC's potential for developing longer-lasting curcumin products.
Article Abstract
The aim of this study was to substitute part of soybean phospholipid (SPC) with hydrogenated soybean phospholipid (HSPC) in curcumin-loaded liposomes (Cur-LP), in order to further enhance stability and release performances of curcumin. When the SPC/HSPC mass ratio changed from 10:0 to 5:5, vesicle size, encapsulation efficiency and alkali resistance of curcumin increased, although a small decrease in centrifugal stability was observed. Salt stability became worse as more HSPC was used (3:7 and 0:10). Owing storage at 4 °C and 25 °C, Cur-LP at a SPC/HSPC mass ratio of 5:5 performed well considering vesicle size, lipid oxidation and curcumin retention. These vesicles displayed also the best sustained-release performance in simulated digestion, attributed to the tighter lipid packing in membranes as indicated by fluorescence probes, DSC and FTIR. This study can guide the development of a Cur-LP product with improved shelf-life stability by using HSPC.
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| http://dx.doi.org/10.1016/j.foodchem.2020.126973 | DOI Listing |
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