We report the synthesis, X-ray crystal structure, and molecular recognition properties of pillar[n]arene derivative P[6]AS, which we refer to as Pillar[6]MaxQ along with analogues P[5]AS and P[7]AS toward guests 1-18. The ultratight binding affinity of P[5]AS and P[6]AS toward quaternary (di)ammonium ions renders them prime candidates for in vitro and in vivo non-covalent bioconjugation, for imaging and delivery applications, and as in vivo sequestration agents.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487980 | PMC |
| http://dx.doi.org/10.1002/anie.202005902 | DOI Listing |
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Pillar[n]MaxQ: A New High Affinity Host Family for Sequestration in Water.
Angew Chem Int Ed Engl
August 2020
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.
We report the synthesis, X-ray crystal structure, and molecular recognition properties of pillar[n]arene derivative P[6]AS, which we refer to as Pillar[6]MaxQ along with analogues P[5]AS and P[7]AS toward guests 1-18. The ultratight binding affinity of P[5]AS and P[6]AS toward quaternary (di)ammonium ions renders them prime candidates for in vitro and in vivo non-covalent bioconjugation, for imaging and delivery applications, and as in vivo sequestration agents.
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