Introduction: Smoking is the leading cause of preventable death accounting for about 0.48 million deaths in the US every year. Across the socioeconomic status (SES) gradient smoking prevalence differs greatly, with those of lower SES smoking at much higher rates than those of higher SES. Previous studies have shown relationships between socioeconomic status, financial strain, and smoking. However, little research has explored the possibility that financial strain might mediate the relationship between socioeconomic status and smoking. Thus, the goal of the current study was to determine whether financial strain was a mediating factor in the relationship between socioeconomic status and smoking.
Methods: Participants (N=238) were primarily female (67.6%) and African-American adults (51.7%) from the Dallas metropolitan area. The majority of the sample reported that they did not currently smoke (n=164). Participants who reported currently smoking at baseline (n=74) smoked an average of 9.96 (SD=10.79) cigarettes per day.
Results: Analyses revealed that financial strain partially mediates the relationship between socioeconomic status and smoking status. Additionally, financial strain was found to significantly partially mediate the relationship between socioeconomic status and cigarettes smoked prospectively over the next 7 days.
Conclusions: Overall, findings suggest that greater financial strain may be one factor that links SES with current smoking and smoking level among those who smoke.
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http://dx.doi.org/10.18332/tpc/102258 | DOI Listing |
Curr Res Toxicol
December 2024
Institute of Nutrition and Food Science, Department of Food Safety, University of Bonn, Germany.
The anthraquinone dye Alizarin Red S (ARS) is used for marking live animals, specifically as a tool for monitoring the stock of the endangered European eel by marking caught fish with ARS before releasing the eels back into the wild. As ARS can be found in recaptured eels even years later, knowledge of potential health hazards of ARS is essential for assessing the food safety of eels marked with ARS. As the compound class of anthraquinones is known for their genotoxic and carcinogenic properties, concerns were raised regarding the food safety of marked eels.
View Article and Find Full Text PDFToxicol Rep
June 2025
Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, El Buhouth St., Dokki, Cairo 12622, Egypt.
Doxorubicin (DOX) is a powerful antineoplastic FDA-approved anthracycline-derived antibiotic and is considered as the most suitable intervention for solid tumors and hematological cancers therapy. However, its therapeutic application is highly limited due to acute and chronic renal, hematological and testicular toxicity. Oxidative stress, lipid peroxidation and apoptosis in germ cells as well as low sperm count, motility and disturbing steroidogenesis are the principal machineries of DOX-induced testicular toxicity.
View Article and Find Full Text PDFToxicol Rep
June 2025
Era College of Pharmacy, Era University, Sarfarajgung, Lucknow-Hardoi Road, Lucknow, Uttar Pradesh, India.
Copper (Cu) dysregulation, often stemming from ATP7B gene mutations, exacerbates neurological disorders like Huntington's, Alzheimer's, and Parkinson's diseases. Monoisoamyl 2,3-dimercaptosuccinic acid (MiADMSA) shows promise in mitigating Cu induced neurotoxicity by chelating intracellular Cu ions, reducing oxidative stress, and restoring antioxidant enzyme function. However, challenges such as poor bioavailability hinder its therapeutic efficacy.
View Article and Find Full Text PDFSynth Syst Biotechnol
June 2025
Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 214122, China.
Riboflavin, an important vitamin utilized in pharmaceutical products and as a feed additive, is mainly produced by metabolically engineered bacterial fermentation. However, the reliance on antibiotics in the production process leads to increased costs and safety risks. To address these challenges, an antibiotic-free riboflavin producer was constructed using metabolic engineering approaches coupled with a novel plasmid stabilization system.
View Article and Find Full Text PDFAm Heart J Plus
January 2025
University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.
Objective: Evaluate the relationship of cathepsin-D (CD) on disease severity and clinical outcomes for women with peripartum cardiomyopathy.
Background: Cathepsin-D is a protease released during oxidative stress that cleaves prolactin (PRL) generating a 16 kDa fragment that is pro-apoptotic, anti-angiogenic, and has been implicated in the pathogenesis of peripartum cardiomyopathy (PPCM).
Methods: In 99 women with newly diagnosed PPCM enrolled in the Investigation in Pregnancy Associated Cardiomyopathy (IPAC) study, CD levels were assessed by ELISA from serum obtained at study entry.
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