Colorectal cancer is the third common cancer in this world, accounting for more than 1 million cases each year. However, detailed etiology and mechanism of colorectal cancer have not been fully understood. For example, cyclooxygenase-2 (COX-2) and its product prostaglandin E (PGE) have been closely linked to its occurrence, progression and prognosis. However, the mechanisms on how COX-2 and PGE-mediate the pathogenesis of colorectal cancer are obscure. In this review, we have summarized recent advances in studies of pathogenesis and control in colorectal cancer to assist further advances in the research for the cure of the cancer. In addition, the knowledge gained may also guide the audiences for reduction of the risk and control of this deadly disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211146 | PMC |
| http://dx.doi.org/10.7150/ijms.44439 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Adapting the MUSIQ Calculator for Practice Facilitators to Evaluate Primary Care Clinic Performance in a Colorectal Cancer Screening Quality Improvement Project.
J Prim Care Community Health
March 2025
West Virginia University School of Medicine, Morgantown, WV, USA.
The Model for Understanding Success in Quality (MUSIQ) is a framework designed to understand the contextual factors that can influence healthcare quality improvement (QI) initiative implementation. The MUSIQ calculator was originally developed to help clinics identify contextual factors that may affect QI success. This retrospective study adapted the MUSIQ calculator to serve as an evaluative tool for practice facilitators engaged in a colorectal cancer screening initiative.
View Article and Find Full Text PDFAdherence to French dietary guidelines is associated with a reduced risk of mortality in the E3N French prospective cohort.
Nutr J
March 2025
Université Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, 12 Avenue Paul Vaillant Couturier, Villejuif, 94805, France.
Background: Diet is a modifiable risk factor for non-communicable diseases which are the major causes of death worldwide. French dietary guidelines, updated in 2017, provide recommendations for a healthier diet. We aimed to study the association between adherence to these dietary guidelines and mortality in the E3N (Etude Epidémiologique auprès de femmes de l'Education Nationale) French cohort.
View Article and Find Full Text PDFSchisandrin B exerts anti-colorectal cancer effect through CXCL2/ERK/DUSP11 signaling pathway.
Cancer Cell Int
March 2025
Department of Pharmacy, Second Affiliated Hospital of Naval Medical University, No. 415, Fengyang Road, Shanghai, 200003, P. R. China.
Background: Schisandrin B (Sch B) is an active component in Schisandra chinensis exerting anti-cancer effect, but the mechanism is obscure. This study was designed to explore the mechanism of Sch B against colorectal cancer (CRC).
Method: Apparent experiments including cell proliferation, transwell, colony formation, etc.
Proteomics-driven discovery of LCAT as a novel biomarker for liver metastasis in colorectal cancer.
BMC Cancer
March 2025
Department of General Surgery, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning Province, China.
Background: This study aimed to identify molecular markers that influence liver metastasis in colorectal cancer (CRC) and assess their clinical relevance.
Methods: Proteomic analysis compared differential protein expression between CRC patients with liver metastasis (CRLM) and those without (CRNLM). Bioinformatics and survival analyses identified key proteins and validated them using the TCGA database for expression and clinical significance.
CBX3 promotes multidrug resistance by suppressing ferroptosis in colorectal carcinoma via the CUL3/NRF2/GPX2 axis.
Oncogene
March 2025
Department of Biotherapy, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, PR China.
Chemoresistance poses a significant challenge in colorectal cancer (CRC) treatment. However, the mechanisms underlying chemoresistance remain unclear. CBX3 promoted proliferation and metastasis in CRC.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!