AI Article Synopsis
- Proteins are complex machinery in cells that require careful regulation of their functions at both the cellular and molecular levels, involving gene expressions and modifications.
- The study explores strategies proteins use to maintain optimal environments for their functional sites, which are not fully understood yet.
- Three main physicochemical factors are identified for regulating these sites: immediate interactions, solvent accessibility, and conformational flexibility, with examples focusing on Cys and Zn sites in proteins.
Article Abstract
Proteins form complex biological machineries whose functions in the cell are highly regulated at both the cellular and molecular levels. Cellular regulation of protein functions involves differential gene expressions, post-translation modifications, and signaling cascades. Molecular regulation, on the other hand, involves tuning an optimal local protein environment for the functional site. Precisely how a protein achieves such an optimal environment around a given functional site is not well understood. Herein, by surveying the literature, we first summarize the various reported strategies used by certain proteins to ensure their correct functioning. We then formulate three key physicochemical factors for regulating a protein's functional site, namely, (i) its immediate interactions, (ii) its solvent accessibility, and (iii) its conformational flexibility. We illustrate how these factors are applied to regulate the functions of free/metal-bound Cys and Zn sites in proteins.
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| http://dx.doi.org/10.1021/jacs.0c02430 | DOI Listing |
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