AI Article Synopsis
Article Abstract
We evaluated the influence of pine bark extract (PBE) on organs, the cytochrome-P450 (CYP) activities in liver and estrogenic effects in normal and ovariectomized (OVX) female mice. The PBE did not affect organ weights and liver-function indexes (activities of alkaline phosphatase, aspartate amino transferase, and alanine amino transferase) at doses; 0.04%, 0.4%, and 2.0% PBE in the diet, in normal and OVX female mice. In the OVX mice, CYP1A1 activity was significantly higher in the 0.4% and 2.0% PBE groups than in the OVX control group, and in the 0.4% and 2.0% PBE groups were significantly higher than in the 0.04% PBE group. CYP1A2 and 3A4 activities were significantly higher in the 2.0% PBE group than in all other groups. The PBE did not affect uterine weight and femoral bone mineral density at all PBE doses. These results showed that the dose of PBE at the recommended human intake, had no toxic and estrogenic effects in normal female and OVX mice, however, it may need attention to use the excess intake of PBE with some drugs in postmenopausal women.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/1750-3841.15160 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Endohedral boron-doped scandium clusters BSc ( = 2-3, = 3-13): triangular - linear rearrangement of the B dopant.
Dalton Trans
January 2025
Laboratory for Chemical Computation and Modeling, Institute for Computational Science and Artificial Intelligence, Van Lang University, Ho Chi Minh City, Vietnam.
A theoretical investigation, employing density functional theory with the PBE functional and the Def2-TZVP basis set, comprehensively explores the geometric and electronic structures and properties of the boron doped scandium clusters BSc with = 2-3 and = 3-13. Introduction of B atoms significantly enhances the stability of the resulting clusters with respect to the initial counterparts. As the number of B atoms increases, the stability of the doped clusters improves, following the order: BSc > BSc > BSc > Sc.
View Article and Find Full Text PDFGenome-wide association mapping of bruchid resistance loci in soybean.
PLoS One
January 2025
Department of Agricultural Production, College of Agricultural and Environmental Sciences, Makerere University, Kampala, Uganda.
Soybean is a globally important industrial, food, and cash crop. Despite its importance in present and future economies, its production is severely hampered by bruchids (Callosobruchus chinensis), a destructive storage insect pest, causing considerable yield losses. Therefore, the identification of genomic regions and candidate genes associated with bruchid resistance in soybean is crucial as it helps breeders to develop new soybean varieties with improved resistance and quality.
View Article and Find Full Text PDFBeyond Fang's fury: a computational study of the enzyme-membrane interaction and catalytic pathway of the snake venom phospholipase A toxin.
Chem Sci
January 2025
LAQV/Requimte, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto Rua do Campo Alegre, s/n 4169-007 Porto Portugal
Snake venom-secreted phospholipases A (svPLAs) are critical, highly toxic enzymes present in almost all snake venoms. Upon snakebite envenomation, svPLAs hydrolyze cell membrane phospholipids and induce pathological effects such as paralysis, myonecrosis, inflammation, or pain. Despite its central importance in envenomation, the chemical mechanism of svPLAs is poorly understood, with detrimental consequences for the design of small-molecule snakebite antidotes, which is highly undesirable given the gravity of the epidemiological data that ranks snakebite as the deadliest neglected tropical disease.
View Article and Find Full Text PDFAnalytical solution of seismic power-based equation of motion.
Heliyon
October 2024
Department of Civil Engineering, International University of Business Agriculture and Technology, Dhaka, 1230, Bangladesh.
This research proposes an innovative power-based equation of motion (PBEM) for the single degree of freedom (SDOF) system considering seismic excitation. The external or input frequency function, solution of time, relation between external and kinetic powers, and equation of strain-power (SP) are obtained by solving the power balance equation (PBE). The external frequency function is related to both the particular and total solutions of the PBEM.
View Article and Find Full Text PDFHigh-pressure phase transitions of series of catenated nitrogen energetic crystals N (x = 4, 8, 10): A comparative DFT-D study.
J Mol Model
October 2024
State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing, 100081, People's Republic of China.
Context: High-pressure chemistry has advantages in exploring novel energetic materials and is the key to the development of new high-energy materials. The complexity and danger of experimental processes require a deeper understanding by advanced simulation techniques. Therefore, a high-precision comparative DFT-D study was performed to investigate the effect of pressure on series of catenated nitrogen energetic crystals.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!