Anti-anaemic effect of ethanol leaf extract of on cyclophosphomide-induced anaemia in rats.

Background: The folkloric claim that (Chaya) could ameliorate anaemia requires scientific revalidation in anaemic models.

Objective: The aim of this study is to investigate the anti-anaemic effect of on cyclophosphamide-induced anaemia in rats.

Methods: The leaves of were collected, dried and extracted with ethanol. Twenty five Wistar Albino rats weighing 120-180 kg were used. Anaemia was induced in groups 2, 3, 4 and 5 with a single injection of cyclophosphamide, while group 1 served as a negative control without anemia and was treated with 0.5 mL of normal saline, Group 2 rats were treated with 100 mg/kg body weight of Group 3 rats were treated with 500 mg/kg body weight of Group 4 served as the positive control rats and was treated with 0.5 mL of normal saline. Group 5 which served as the standard control rats and were treated with 5 mg/kg body weight of standard drug Chemiron. The treated lasted for two weeks during which blood samples were collected from each rat for haematological analysis.

Results: The result shows that hematological parameters were elevated in groups 2, 3 and 5 rats treated with 100 mg/kg and 500 mg/kg body weight of ethanol extract of and chemiron respectively.

Conclusions: Ethanol leaf extract of at a graded dose of 500 mg/kg body weight had higher ameliorative effect on the haematological parameters of cyclophosphamide-induced anemia in rats.