Effective coastal aquifer management typically relies on numerical models to analyze the seawater intrusion (SI) process. Before using groundwater simulation models to predict the extent of SI in the future, preparing input data is an extremely necessary and important step. For precipitation and sea-level rise (SLR), which are two of the most influential factors for SI, it is difficult to precisely forecast their variations. Current studies of using numerical models to predict future SI often overlook the uncertainty of these two factors. This can result in compromised predictions of SI. In this study, a three-dimensional variable-density groundwater simulation model was established for a coastal area in Longkou, China. Then, the Monte Carlo method was applied to perform uncertainty analysis for the input data of precipitation and SLR of the SI model. In order to reduce the huge computational load brought by repeated invocation of the SI model during the process of Monte Carlo simulation, a surrogate model based on a multi-gene genetic programming (MGGP) method was developed to replace the SI simulation model for calculation. A comparison between the MGGP surrogate model and the Kriging surrogate model was carried out, and the results show that the MGGP surrogate model has a distinct advantage over the Kriging surrogate model in approximating the excitation-response relationship of the variable-density groundwater simulation model. Through statistical analysis of Monte Carlo simulation results, an object and reasonable risk assessment of SI for the study area was obtained. This study suggests that it is essential to take the uncertainty of precipitation and SLR into account when modeling and predicting the extent of SI.
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http://dx.doi.org/10.1007/s11356-020-09177-2 | DOI Listing |
Front Public Health
December 2024
Wastewater Technology Research, Wastewater Disposal, German Environment Agency, Berlin, Germany.
Introduction: Accurate and consistent data play a critical role in enabling health officials to make informed decisions regarding emerging trends in SARS-CoV-2 infections. Alongside traditional indicators such as the 7-day-incidence rate, wastewater-based epidemiology can provide valuable insights into SARS-CoV-2 concentration changes. However, the wastewater compositions and wastewater systems are rather complex.
View Article and Find Full Text PDFCan J Kidney Health Dis
December 2024
Department of Medicine, Western University, London, ON, Canada.
Background: Kidney transplant recipients are uniquely exposed to the disordered bone metabolism associated with chronic kidney disease beginning before transplantation followed by chronic corticosteroid use after transplantation. Previous efforts to synthesize the rapidly accruing evidence regarding estimation and management of fracture risk in kidney transplant recipients are outdated and incomplete.
Objective: To synthesize the evidence informing the overall incidence, patient-specific risk prediction, and methods of prevention of fractures in patient living with a kidney transplant.
Sci Total Environ
December 2024
Center for Environmental Measurement and Modeling, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Epidemiologic studies of ambient fine particulate matter (PM) and ozone (O) often use outdoor concentrations from central-site monitors or air quality model estimates as exposure surrogates, which can result in exposure errors. We previously developed an exposure model called TracMyAir, which is an iPhone application that determines seven tiers of individual-level exposure metrics for ambient PM and O using outdoor concentrations, home building characteristics, weather, time-activities. The exposure metrics with increasing information needs and complexity include: outdoor concentration (C, Tier 1), building infiltration factor (F, Tier 2), indoor concentration (C, Tier 3), time spent in microenvironments (ME) (T, Tier 4), personal exposure factor (F, Tier 5), exposure (E, Tier 6), and inhaled dose (D, Tier 7).
View Article and Find Full Text PDFSci Rep
December 2024
Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology, Gdansk, 80-233, Poland.
Recent years have witnessed a tremendous popularity growth of optimization methods in high-frequency electronics, including microwave design. With the increasing complexity of passive microwave components, meticulous tuning of their geometry parameters has become imperative to fulfill demands imposed by the diverse application areas. More and more often, achieving the best possible performance requires global optimization.
View Article and Find Full Text PDFToxins (Basel)
December 2024
Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany.
Hemolytic-uremic syndrome (HUS) is a systemic complication of an infection with Shiga toxin (Stx)-producing enterohemorrhagic , primarily leading to acute kidney injury (AKI) and microangiopathic hemolytic anemia. Although free heme has been found to aggravate renal damage in hemolytic diseases, the relevance of the heme-degrading enzyme heme oxygenase-1 (HO-1, encoded by ) in HUS has not yet been investigated. We hypothesized that HO-1 also important in acute phase responses in damage and inflammation, contributes to renal pathogenesis in HUS.
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