Silicone wristbands are promising passive samplers to support epidemiological studies in characterizing exposure to organic contaminants; however, investigating associated health risks remains challenging because of the latency period for many chronic diseases that take years to manifest. Dogs provide valuable insights as sentinels for exposure-related human disease because they share similar exposures in the home, have shorter life spans, share many clinical/biological features, and have closely related genomes. Here, we evaluated exposures among pet dogs and their owners using silicone dog tags and wristbands to determine if contaminant levels were correlated with validated exposure biomarkers. Significant correlations between measures on dog tags and wristbands were observed ( = 0.38-0.90; < 0.05). Correlations with their respective urinary biomarkers were stronger in dog tags compared to that in human wristbands ( = 0.50-0.71; < 0.01) for several organophosphate esters. This supports the value of using silicone bands with dogs to investigate health impacts on humans from shared exposures.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655112 | PMC |
| http://dx.doi.org/10.1021/acs.est.9b06605 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Collective responses of flocking sheep (Ovis aries) to a herding dog (border collie).
Commun Biol
November 2024
Centre de Recherches sur la Cognition Animale, Centre de Biologie Intégrative, CNRS, Université de Toulouse - Paul Sabatier, Toulouse, France.
Group-living organisms commonly exhibit collective escape responses, yet how information flows among group members in these events remains an open question. Here, we study the collective responses of a sheep flock (Ovis aries) to a shepherd dog (border collie) in a driving task between two well-defined target points. We collected high-resolution spatiotemporal data from 14 sheep and the dog, using Ultra-Wide-Band tags attached to each individual.
View Article and Find Full Text PDFImproving the diffraction quality of heat-shock protein 47 crystals.
Acta Crystallogr F Struct Biol Commun
November 2024
Molecular Structure & Design, Bristol Myers Squibb Research & Development, PO Box 4000, Princeton, NJ 08543-4000, USA.
Heat-shock protein 47 (HSP47) is a potential target for inhibitors that ameliorate fibrosis by reducing collagen assembly. In an effort to develop a structure-based drug-design system, it was not possible to replicate a previous literature result (PDB entry 4au4) for apo dog HSP47; instead, crystal forms were obtained in which pairs of dog HSP47 molecules interacted through a noncleavable C-terminal His-tag to build up tetramers, all of which had multiple molecules of HSP47 in the asymmetric unit and none of which diffracted as well as the literature precedent. To overcome these difficulties, a two-pronged approach was followed: (i) the His-tag was moved from the C-terminus to the N-terminus and was made cleavable, and (ii) Adnectin (derived from the tenth domain of human fibronectin type III) crystallization chaperones were developed.
View Article and Find Full Text PDFSilicone tags as an effective method of monitoring environmental contaminant exposures in a geographically diverse sample of dogs from the Dog Aging Project.
Front Vet Sci
August 2024
Population Health Sciences Department, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States.
Introduction: Companion animals offer a unique opportunity to investigate risk factors and exposures in our shared environment. Passive sampling techniques have proven effective in capturing environmental exposures in dogs and humans.
Methods: In a pilot study, we deployed silicone monitoring devices (tags) on the collars of a sample of 15 dogs from the Dog Aging Project Pack cohort for a period of 120 h (5 days).
Addressing the need for individual-level exposure monitoring for firefighters using silicone samplers.
J Expo Sci Environ Epidemiol
July 2024
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
Background: Firefighters are occupationally exposed to hazardous chemical mixtures. Silicone passive sampling devices capture unique exposures over time with minimal impact to the participant and allow for the analysis of a broad chemical space.
Objective: Silicone dog tags were worn by firefighters while on- and off-duty to measure individual exposures, identify potential occupational exposures, and assess their relation to occupational variables including fire response frequency, rank, and years as a firefighter.
Changes of the salivary and serum proteome in canine hypothyroidism.
Domest Anim Endocrinol
January 2024
Interlab-UMU, Regional Campus of International Excellence "Mare Nostrum" University of Murcia, 30100 Murcia, Spain. Electronic address:
In this study, changes in salivary and serum proteome of dogs with hypothyroidism were studied using tandem mass tags (TMT) labelling and liquid chromatography-mass spectrometry (LC-MS/MS). Saliva and serum proteome from 10 dogs with hypothyroidism were compared with 10 healthy dogs. In saliva, a total of seven proteins showed significant changes between the two groups, being six downregulated and one upregulated, meanwhile, in serum, a total of six proteins showed significant changes, being five downregulated and one upregulated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!