Euphopanes A-C, three new diterpenoids from .

Nat Prod Res

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.

Published: January 2022

Three new diterpenoids, euphopanes A-C (-), including one -isopimarane (), one -abietane () and one cembrane (), along with five known compounds (-) were isolated from the roots of . Their structures were elucidated by extensive spectroscopic analysis, and the absolute configurations of compounds - were determined by ECD calculations. All the isolates were screened for the cytotoxicity against three cancer cell lines (C4-2B, C42B/ENZR, and MDA-MB-231), and compounds , , and showed significant cytotoxicity against human prostate cancer cells C4-2B with IC values of 14.3, 16.9, and 15.3 μM, respectively.

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Source
http://dx.doi.org/10.1080/14786419.2020.1765342DOI Listing

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