Although the cytosolic Ca signalling event in phagocytosis is well established, and the mechanism for generating such signals also understood, the target for the Ca signal and how this relates to the phagocytic outcome is less clear. In this chapter, we present the evidence for a role of the Ca activated protease, calpain, in phagocytosis. The abundant evidence for Ca changes and calpain activation during cell shape changes is extended to include the specific cell shape change which accompanies phagocytosis. The discussion therefore includes a brief description of the domain structure of calpain and their functions. Also the mechanism by which calpain activation is limited at the cell periphery subdomains, and how this would allow phagocytic pseudopodia to form locally.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-3-030-40406-2_8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Proteomic Profiling of Medullary Thyroid Cancer Identifies CAPN1 as a Key Regulator of NF1 and RET Fueled Growth.
Thyroid
January 2025
Department of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio, USA.
Medullary thyroid cancer (MTC) is a frequently metastatic tumor of the thyroid that develops from the malignant transformation of C-cells. These tumors most commonly have activating mutations within the RET or RAS proto-oncogenes. Germline mutations within RET result in C-cell hyperplasia, and cause the MTC pre-disposition disorder, multiple endocrine neoplasia, type 2A (MEN2A).
View Article and Find Full Text PDFSagittaria sagittifolia polysaccharide extract regulates Nrf2 to improve endoplasmic reticulum stress-mediated apoptosis in rat cataracts and HLEB3 cells.
Int J Biol Macromol
January 2025
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102446, China. Electronic address:
Age-related cataract (ARC) remains the leading cause of blindness worldwide. Sagittaria sagittifolia polysaccharide (SSP) extract, a key component of Sagittaria sagittifolia L., exhibits anti-oxidant and anti-apoptotic effects with potential applications in ARC.
View Article and Find Full Text PDFSlowly digestible starch impairs growth performance of broiler chickens offered low-protein diet supplemental higher amino acid densities by inhibiting the utilization of intestinal amino acid.
J Anim Sci Biotechnol
January 2025
Department of Animal Nutrition and Feed Science, State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Background: The synchronized absorption of amino acids (AAs) and glucose in the gut is crucial for effective AA utilization and protein synthesis in the body. The study investigated how the starch digestion rate and AA levels impact intestinal AA digestion, transport and metabolism, breast muscle protein metabolism, and growth in grower broilers. A total of 720 21-day-old healthy male Arbor Acres Plus broilers were randomly assigned to 12 treatments, each with 6 replicates of 10 birds.
View Article and Find Full Text PDFQuality Enhancement Techniques for Cow Meat: Current Approaches and Future Directions.
Food Sci Anim Resour
January 2025
Institutes of Green Bio Science & Technology, Seoul National University, Pyeongchang 25354, Korea.
The quality grade of cow meat is often lower than that of steer meat, resulting in economic losses and reduced consumer satisfaction. This review explores various strategies for improving the quality of cow meat, with a focus on slaughter and post-slaughter practices. Certain slaughter methods, including electrical stimulation and suspension techniques, have been shown to improve meat tenderness by alleviating rigor mortis and inducing an increase in sarcomere length.
View Article and Find Full Text PDFPiezo1 aggravates ischemia/reperfusion-induced acute kidney injury by Ca-dependent calpain/HIF-1α/Notch signaling.
Ren Fail
December 2025
Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
Macrophages play a vital role in the inflammation and repair processes of ischemia/reperfusion-induced acute kidney injury (IR-AKI). The mechanosensitive ion channel Piezo1 is significant in these inflammatory processes. However, the exact role of macrophage in IR-AKI is unknown.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!