Neuroscientists draw lines of separation among structures and functions that they judge different, arbitrarily excluding or including issues in our description, to achieve positive demarcations that permits a pragmatic treatment of the nervous activity based on regularity and uniformity. However, uncertainty due to disconnectedness, lack of information and absence of objects' sharp boundaries is a troubling issue that prevents these scientists to select the required proper sets/subsets during their experimental assessment of natural and artificial neural networks. Starting from the detection of metamorphoses of shapes inside a Euclidean manifold, we propose a technique to detect the topological changes that occur during their reciprocal interactions and shape morphing. This method, that allows the detection of topological holes development and disappearance, makes it possible to solve the problem of uncertainty in the assessment of countless dynamical phenomena, such as cognitive processes, protein homeostasis deterioration, fire propagation, wireless sensor networks, migration flows, and cosmic bodies analysis.
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http://dx.doi.org/10.1007/s11571-020-09574-w | DOI Listing |
Phys Rev Lett
December 2024
California Institute of Technology, Division of Chemistry and Chemical Engineering, Pasadena, California 91125, USA.
We introduce a change of perspective on tensor network states that is defined by the computational graph of the contraction of an amplitude. The resulting class of states, which we refer to as tensor network functions, inherit the conceptual advantages of tensor network states while removing computational restrictions arising from the need to converge approximate contractions. We use tensor network functions to compute strict variational estimates of the energy on loopy graphs, analyze their expressive power for ground states, show that we can capture aspects of volume law time evolution, and provide a mapping of general feed-forward neural nets onto efficient tensor network functions.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
University of Strathclyde, Institute of Photonics, SUPA Dept of Physics, Glasgow, United Kingdom.
We report a spiking flip-flop memory mechanism that allows controllably switching between neural-like excitable spike-firing and quiescent dynamics in a resonant tunneling diode (RTD) neuron under low-amplitude (<150 mV pulses) and high-speed (ns rate) inputs pulses. We also show that the timing of the set-reset input pulses is critical to elicit switching responses between spiking and quiescent regimes in the system. The demonstrated flip-flop spiking memory, in which spiking regimes can be controllably excited, stored, and inhibited in RTD neurons via specific low-amplitude, high-speed signals (delivered at proper time instants) offers high promise for RTD-based spiking neural networks, with the potential to be extended further to optoelectronic implementations where RTD neurons and RTD memory elements are deployed alongside for fast and efficient photonic-electronic neuromorphic computing and artificial intelligence hardware.
View Article and Find Full Text PDFBioinformatics
January 2025
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Motivation: The accurate prediction of O-GlcNAcylation sites is crucial for understanding disease mechanisms and developing effective treatments. Previous machine learning models primarily relied on primary or secondary protein structural and related properties, which have limitations in capturing the spatial interactions of neighboring amino acids. This study introduces local environmental features as a novel approach that incorporates three-dimensional spatial information, significantly improving model performance by considering the spatial context around the target site.
View Article and Find Full Text PDFBioinformatics
January 2025
School of Computing and Artificial Intelligence, Southwest Jiaotong University, Sichuan 611756, China.
Motivation: The rapid development of single-cell RNA sequencing (scRNA-seq) has significantly advanced biomedical research. Clustering analysis, crucial for scRNA-seq data, faces challenges including data sparsity, high dimensionality, and variable gene expressions. Better low-dimensional embeddings for these complex data should maintain intrinsic information while making similar data close and dissimilar data distant.
View Article and Find Full Text PDFJ Acoust Soc Am
January 2025
Urban Construction Center of Lucheng District of Wenzhou, Wenzhou, 325000, China.
The identification of vibration and reconstruction of sound fields of plate structures are important for understanding the vibroacoustic characteristics of complex structures. This paper presents a data-physics driven (DPD) model integrated with transfer learning (DPDT) for high-precision identification and reconstruction of vibration and noise radiation of plate structures. The model combines the Kirchhoff-Helmholtz integral equation with convolutional neural networks, leveraging physical information to reduce the need for extensive data.
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