AI Article Synopsis
- The microenvironment around germinal center B cells, along with their interactions with immune cells, is important for the development and growth of follicular lymphoma (FL).
- Recent studies highlight how genetic changes in the CTSS and EZH2 genes affect these cell interactions, potentially influencing the behavior of FL.
- The findings could have significant implications for developing immunotherapy strategies for treating follicular lymphoma.
Article Abstract
Interactions between germinal center B cells and immune cells in the microenvironment can play integral roles in transformation and growth of follicular lymphoma (FL). Three recent studies, two in this issue of Cancer Cell and one in Cell Reports, elucidate how genetic alterations in CTSS and EZH2 impact these interactions, with implications for FL immunotherapy.
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| http://dx.doi.org/10.1016/j.ccell.2020.04.008 | DOI Listing |
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