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| http://dx.doi.org/10.1093/jtm/taaa073 | DOI Listing |
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Rapid emergence, transmission, and evolution of KPC and NDM coproducing carbapenem-resistant Klebsiella pneumoniae.
Microbiol Res
January 2025
Research Institute of General Surgery, Jinling Hospital, the Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. Electronic address:
Article Synopsis
- Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major clinical concern due to limited treatment options, worsened by the emergence of KPC and NDM co-producing strains.
- A study identified 15 strains involved in an outbreak affecting 10 patients between October 2020 and May 2021, characterized by a highly stable hybrid plasmid co-harboring resistance genes.
- Global genomic analysis of 327 KPC-NDM-CRKP genomes revealed potential transmission events during the COVID-19 period, highlighting the urgent public health threat posed by these resistant strains.
The impact of COVID-19 public health and social measures on years of potential life lost.
J Emerg Manag
January 2025
Rocky Mountain Center for Occupational and Environmental Health, University of Utah, Salt Lake City, Utah.
Background: To determine the impacts of statewide coronavirus disease 2019 (COVID-19)-related public health and social measures (PHSMs) and attempted pandemic mitigation measures on years of potential life lost (YPLL).
Methods: The "openness score" of each state during the COVID-19 pandemic was obtained using two open-source sites, the Multistate openness score and the Wallethub openness score. These scores combined various PHSMs, such as restrictions on gatherings and closing various types of businesses.
Lyrics do matter: how "coping songs" relate to well-being goals. The COVID pandemic case.
Front Psychol
December 2024
The Hebrew University Business School, The Hebrew University, Jerusalem, Israel.
Introduction: In stressful times, people often listen to "coping songs" that help them reach emotional well-being goals. This paper is a first attempt to map the connection between an individual's well-being goals and their chosen coping song.
Methods: We assembled a large-scale dataset of 2,804 coping songs chosen by individuals from 11 countries during COVID-19 lockdown.
Infants born during COVID-19 pandemic experience increased susceptibility to airway hyperresponsiveness.
Front Allergy
December 2024
Allergy and Clinical Immunology Unit, Meir Medical Center, Kfar Saba, Israel.
Background: Asthma, allergic rhinitis, atopic dermatitis, and food allergy are type 2 inflammation diseases. Since the 1960s, the prevalence of those diseases has steadily increased, presumably due to the "Hygiene hypothesis" which suggests that early exposure of infants to pathogens, siblings, and environmental dust, has a protective effect against the development of allergic diseases. The COVID-19 pandemic increased environmental hygiene due to lockdowns, masks, and social distancing.
View Article and Find Full Text PDFDe Novo Design of Lipopeptide-Based β-Sheet-Like Self-Assemblies: A Strategy to Develop Fusion Inhibitors as Broad-Spectrum Antivirals.
Chemistry
December 2024
Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, 741 246, India.
The recent surge in emerging viral infections warrants the design of broad-spectrum antivirals. We aim to develop a lead molecule that targets a common biochemical feature of many enveloped viruses, membrane fusion. To achieve the broad-spectrum ability, instead of targeting the fusion machinery, we plan to modulate the physicochemical properties of the host and viral membranes to block fusion.
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