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A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galα1-3Gal epitope. | LitMetric
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A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galα1-3Gal epitope.

Jiaxing Wang Beverly Ellis Bin Zhou Lisa M Eubanks Steven Blake Kim D Janda

Chem Commun (Camb)

Department of Chemistry, Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, The Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Published: June 2020

A double conjugation strategy was implemented to produce an anti-fentanyl vaccine, which was predicated upon preformed-antibody-assisted antigen presentation. The new vaccine was found to reduce the psychoactive effects of fentanyl without the addition of the immunostimulant CpG oligodeoxynucleotide.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398699PMC
http://dx.doi.org/10.1039/d0cc02107eDOI Listing

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