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The discovery, structure, and function of 5-HTR1E serotonin receptor.
Cell Commun Signal
September 2023
Section On Cellular Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, NICHD, NIH, 49, Convent Drive, Bldg 49, Rm 6A-10, Bethesda, MD, 20892, USA.
Serotonin (5-hydroxytryptamine, 5-HT) is a unique neurotransmitter which can regulate various biological processes by activating thirteen different receptors. These serotonin receptors are divided into seven different classes based on their structure and functions. Since these receptors co-express in various tissue and cell types and share the same ligand (5-HT), it has been a challenge for the researchers to define specific pathway and separate physiological role for each of these serotonin receptors.
View Article and Find Full Text PDFThe Serotonin 1A (5-HT) Receptor as a Pharmacological Target in Depression.
CNS Drugs
July 2023
Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, OX3 7JX, UK.
Clinical depression is a common, debilitating and heterogenous disorder. Existing treatments for depression are inadequate for a significant minority of patients and new approaches are urgently needed. A wealth of evidence implicates the serotonin 1A (5-HT) receptor in the pathophysiology of depression.
View Article and Find Full Text PDFOpposing effects of 5-HT1A receptor agonist buspirone on supraspinal abdominal pain transmission in normal and visceral hypersensitive rats.
J Neurosci Res
October 2023
Laboratory of Cortico-Visceral Physiology, Pavlov Institute of Physiology of the Russian Academy of Sciences, Saint Petersburg, Russia.
Article Synopsis
- The study investigates the role of serotonergic 5-HT1A receptors in visceral pain, particularly focusing on their effects in male Wistar rats recovering from colitis.
- Researchers found that post-colitis, the response of neurons in the caudal ventrolateral medulla to colorectal distension was heightened, indicating an increase in visceral pain sensitivity.
- The 5-HT1A agonist buspirone, which normally reduces pain responses, instead exacerbated pain in the post-colitis rats, suggesting a shift from a pain-relieving to a pain-promoting role for these receptors in the context of intestinal hypersensitivity.
Ulotaront: a TAAR1/5-HT1A agonist in clinical development for the treatment of schizophrenia.
Expert Opin Investig Drugs
December 2022
Department of Psychiatry and Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, New York, NY, USA.
Introduction: Current antipsychotics are postsynaptic dopamine-2(D) receptor blockers, which often, but not always, effectively improve acute psychotic symptoms and prevent relapse in schizophrenia and other severe mental disorders, but are associated with various side effects, including parkinsonism, akathisia, sedation/somnolence, and cardiometabolic alterations. Furthermore, the efficacy of current antipsychotics for negative and cognitive symptoms in schizophrenia is limited. Ulotaront is a novel trace-amine-associated receptor-1(TAAR1) agonist with serotonin-1A receptor agonist activity, and without postsynaptic D2-receptor antagonism.
View Article and Find Full Text PDFMigraine is a common form of primary headache, affecting up to 1 in every 6 Americans. The pathophysiology is an intricate interplay of genetic factors and environmental influence and is still being elucidated in ongoing studies. The trigeminovascular system is now known to have a significant role in the initiation of migraines, including the release of pain mediators such as CGRP and substance P.
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