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Tissue-Adhesive Paint of Silk Microparticles for Articular Surface Cartilage Regeneration. | LitMetric

Tissue-Adhesive Paint of Silk Microparticles for Articular Surface Cartilage Regeneration.

ACS Appl Mater Interfaces

Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

Published: May 2020

AI Article Synopsis

  • * This study developed a tissue-adhesive joint surface paint (JS-Paint) made from NB-coated silk fibroin microparticles, enhancing cartilage regeneration by promoting cell adhesion and proliferation.
  • * JS-Paint demonstrated significant cartilage regeneration and improvement of joint surface smoothness in a rabbit model just six weeks after treatment, showing potential for advancing therapies for early to mid-stage osteoarthritis.

Article Abstract

Current biomaterials and tissue engineering techniques have shown a promising efficacy on full-thickness articular cartilage defect repair in clinical practice. However, due to the difficulty of implanting biomaterials or tissue engineering constructs into a partial-thickness cartilage defect, it remains a challenge to provide a satisfactory cure in joint surface regeneration in the early and middle stages of osteoarthritis. In this study, we focused on a ready-to-use tissue-adhesive joint surface paint (JS-Paint) capable of promoting and enhancing articular surface cartilage regeneration. The JS-Paint is mainly composed of -(2-aminoethyl)-4-(4-(hydroxymethyl)-2-methoxy-5-nitrosophenoxy) butanamide (NB)-coated silk fibroin microparticles and possess optimal cell adhesion, migration, and proliferation properties. NB-modified silk fibroin microparticles can directly adhere to the cartilage and form a smooth layer on the surface via the photogenerated aldehyde group of NB reacting with the -NH groups of the cartilage tissue. JS-Paint treatment showed a significant promotion of cartilage regeneration and restored the smooth joint surface at 6 weeks postsurgery in a rabbit model of a partial-thickness cartilage defect. These findings revealed that silk fibroin can be utilized to bring about a tissue-adhesive paint. Thus, the JS-Paint strategy has some great potential to enhance joint surface regeneration and revolutionize future therapeutics of early and middle stages of osteoarthritis joint ailments.

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.0c01776DOI Listing

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