AI Article Synopsis
- A meta-analysis was conducted to explore the link between the interleukin-8 -251A/T polymorphism and the risk of tuberculosis (TB), as previous findings were inconsistent.
- The analysis revealed that the -251A/T polymorphism significantly increases the risk of TB, particularly in African populations, while no significant association was found in Asian populations.
- The study suggests that the -251A/T polymorphism may be a contributing factor to TB risk, but larger studies are needed to validate these findings.
Article Abstract
Objective: The relationship between interleukin-8 () -251A/T polymorphism and tuberculosis (TB) risk remains controversial. Therefore, the present meta-analysis was performed by retrieving relevant studies from the available literature.
Methods: We comprehensively searched three databases to identify eligible literature on the relationship of -251A/T polymorphism with TB risk, calculated pooled odds ratios (OR) with 95% confidence intervals (CI), and subsequent evaluated the heterogeneity and publication bias.
Results: We found that -251A/T polymorphism increased TB risk (AA vs. TT: OR = 2.86, 95%CI: 1.46-5.60; AT vs. TT: OR = 1.64, 95%CI: 1.15-2.34; dominant model: OR = 1.88, 95%CI: 1.24-2.86; recessive model: OR = 1.77, 95%CI: 1.17-2.69). Subgroup analyses based on race revealed that the -251A/T polymorphism might be associated with the risk of TB in African but not Asian individuals.
Conclusion: The -251A/T polymorphism might be related to the risk of TB. Nevertheless, large-scale studies should be performed to confirm the role of -251A/T polymorphism on TB risk.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218964 | PMC |
| http://dx.doi.org/10.1177/0300060520917877 | DOI Listing |
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