A KSO-mediated three-component protocol has been developed for the construction of 3-trifluoroalkylated quinoxalin-2(1)-ones under metal-free conditions. The present reaction could be accomplished through the trifluoroalkylation of quinoxalin-2(1)-ones with unactivated alkenes and Langlois' reagent (CFSONa), which provided a highly attractive approach to access a series of biologically important 3-trifluoroalkylated quinoxalin-2(1)-ones.
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