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We report five new transition-metal complexes that inhibit the urease enzyme. Barbituric acid (), thiobarbituric acid (), isoniazid (), and nicotinamide () ligands were employed in complexation reactions. The resulting complexes were characterized using a variety of analytical techniques including infra-red and UV-vis spectroscopy, H NMR spectroscopy, elemental analysis, and single-crystal X-ray diffraction analysis. We describe two mononuclear complexes with a general formula {[M()(HO)]()(HO)}, where M = Co () and Zn (), a mononuclear complex {[Ni()(HO)]()(HO)} (), and two polymeric chains of a general formula {[M() (HO)]()(HO)}, where M = Co () and Zn (). These complexes displayed significant urease enzyme inhibition with IC values in the range of 3.9-19.9 μM.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203987 | PMC |
| http://dx.doi.org/10.1021/acsomega.0c01089 | DOI Listing |
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