Repetitive sequences can form a variety of alternative DNA structures (non-B DNA) that can modulate transcription, replication, and repair. However, non-B DNA-forming sequences can also stimulate mutagenesis, and are enriched at mutation hotspots in human cancer genomes. Interestingly, different types of non-B DNA stimulate mutagenesis via distinct repair processing mechanisms.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199757 | PMC |
| http://dx.doi.org/10.1080/23723556.2020.1743807 | DOI Listing |
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