AI Article Synopsis
- ARID1A is a protein that helps maintain the stability of telomeres by regulating a cohesin subunit known as STAG1.
- When ARID1A is inactivated, it causes issues during cell division (mitosis) and leads to certain chromosomal changes, but somehow still preserves genomic stability in mutated cancers.
- This research clarifies why ARID1A inactivation causes these mitotic problems yet does not seem to lead to overall genomic instability in certain types of cancers.
Article Abstract
We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit stromal antigen 1 (STAG1). ARID1A inactivation results in mitotic defects and negatively selects gross chromosomal aberrations, resulting in preservation of genomic stability in -mutated cancers. These findings explain the long-standing paradox between mitotic defects caused by ARID1A inactivation and the lack of genomic instability in -mutated cancers.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199758 | PMC |
| http://dx.doi.org/10.1080/23723556.2019.1690923 | DOI Listing |
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