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Comparative Transcriptome Landscape of Mouse and Human Hearts. | LitMetric

Comparative Transcriptome Landscape of Mouse and Human Hearts.

Front Cell Dev Biol

Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan.

Published: April 2020

AI Article Synopsis

  • - The study analyzes the transcriptomic differences between mouse and human organs to better understand organ development, focusing specifically on human cardiomyocyte maturation.
  • - It was discovered that ribosomal genes showed significant differences in expression between the two species, and that developmental ages of organs don't directly correspond between mice and humans.
  • - A new set of maturation marker genes was identified that is more applicable across both species, highlighting the need for human studies rather than solely relying on mouse data for understanding cardiomyocyte maturation.

Article Abstract

Transcriptome landscape of organs from mice and humans offers perspectives on the process of how organs develop and the similarity and diversity in each organ between the species. Among multi-species and multi-organ dataset, which was previously generated, we focused on the mouse and human dataset and performed a reanalysis to provide a more specific perspective on the maturation of human cardiomyocytes. First, we examined how organs diversify their transcriptome during development across and within two species. We unexpectedly identified that ribosomal genes were differentially expressed between mice and humans. Second, we examined the corresponding ages of organs in mice and humans and found that the corresponding developmental ages did not match throughout organs. Mouse hearts at P0-3 and human hearts at 18-19 wpc showed the most proximity in the regard of the transcriptome. Third, we identified a novel set of maturation marker genes that are more consistent between mice and humans. In contrast, conventionally used maturation marker genes only work well with mouse hearts. Finally, we compared human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) in maturation-enhanced conditions to human fetal and adult hearts and revealed that human PSC-CMs only expressed low levels of the potential maturation marker genes. Our findings provide a novel foundation to study cardiomyocyte maturation and highlight the importance of studying human samples rather than relying on a mouse time-series dataset.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188931PMC
http://dx.doi.org/10.3389/fcell.2020.00268DOI Listing

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