Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, México.
Published: June 2019
AI Article Synopsis
Article Abstract
During our ongoing research on fungal strains from unexplored sources, the reinvestigation of the CHCl-MeOH extract of the marine-facultative sp. MEXU 27854 yielded a new -methyl cyclic pentapeptide () along with known butyrolactone II and PF1233 A. In addition, from the marine-facultative MEXU 29901, a new alternariol glucoside, 10-[-D-(4-methoxyl-glucopyranosyl)]-4--methylalternariol () and known alternariol 4-methyl ether, alternariol and beauvericin, were isolated. The structures of and were established by detailed spectroscopic data, and their absolute configuration was ascertained by Marfey's analysis and HRESIMS-MS/MS data for , and by chemical degradation and optical rotation analysis for .
The marine-facultative sp. MEXU 27854, isolated from the Caleta Bay in Acapulco, Guerrero, Mexico, has provided an interesting diversity of secondary metabolites, including a series of rare dioxomorpholines, peptides, and butyrolactones. Here, we report on the genomic data, which consists of 11 contigs (N50~3.
During our ongoing research on fungal strains from unexplored sources, the reinvestigation of the CHCl-MeOH extract of the marine-facultative sp. MEXU 27854 yielded a new -methyl cyclic pentapeptide () along with known butyrolactone II and PF1233 A. In addition, from the marine-facultative MEXU 29901, a new alternariol glucoside, 10-[-D-(4-methoxyl-glucopyranosyl)]-4--methylalternariol () and known alternariol 4-methyl ether, alternariol and beauvericin, were isolated.
Departamento de Química, Centro de Investigación y de Estudios, Avanzados del Instituto Politécnico Nacional , Apartado 14-740, Ciudad de México 07000, México.
Two new compounds, dioxomorpholines 1 and 2, along with three derivatives (3-5) and the known compound PF1233 B (6), were extracted from a marine Aspergillus species.
The structural identification of these compounds was achieved using advanced NMR and HRESIMS techniques, with the absolute configuration of 1 and 2 determined through vibrational circular dichroism spectra analysis.
While compounds 3, 5, and 6 showed no toxicity to various human cancer cell lines, they were effective in inhibiting P-glycoprotein, which helps counteract multidrug resistance, particularly in doxorubicin-resistant cells.
