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An azido coumarin-quinoline conjugated fluorogenic dye: Utilizing amide-iminol tautomerism for HS detection in live MCF-7 cells. | LitMetric

An azido coumarin-quinoline conjugated fluorogenic dye: Utilizing amide-iminol tautomerism for HS detection in live MCF-7 cells.

Spectrochim Acta A Mol Biomol Spectrosc

Department of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

Published: September 2020

AI Article Synopsis

Article Abstract

Detection of HS to analyze some diseases in living lives demands fast response, high selectivity and biocompatibility. Here we designed an azide containing coumarin attached with 8-aminoquinoline via amide backbone (ACAQ) fluorophore as the HS sensing probe. Excellent response time of 6 min, high sensitivity with the limit of detection (LOD) of 14.6 nM and high selectivity with other possible interferences are revealed for ACAQ after characterized by spectroscopy, H NMR titration and LC-MS measurements. The sensing strategy is explained by amide-iminol tautomerism and azide reduction. In addition, the successful visualization measurement suggests the practicability of the probe ACAQ for HS detection in live samples.

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Source
http://dx.doi.org/10.1016/j.saa.2020.118345DOI Listing

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