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Reactive hemophagocytic lymphohistiocytosis: Epidemiological, clinico-biological and etiological profile.
Curr Res Transl Med
December 2024
Department of internal medicine, Hedi Chaker University Hospital, Sfax, Tunisia.
Unlabelled: Hemophagocytic lymphohistiocytosis (HLH) is an hyperinflammatory state resulting from increased secretion of proinflammatory cytokines, which are responsible for clinical, biological and cytological manifestations.
Objective: The aim of our study is to describe the epidemiological, clinical, biological, etiological and evolutionary profile of HLH in Tunisia.
Methods: A retrospective study that involved patients, with images of hemophagocytosis in myelograms analyzed at the laboratory of biological hematology of the University Hospital "Hédi-Chaker" of Sfax-Tunisia, followed at these departments: hematology, internal medicine, department of infectious-diseases and department of gastroenterology, (June2017- May2021).
Clinico-Metabolic Profile and Follow-Up of Familial Cases Compared to Sporadic Cases in a Lyon Series of Type 1 Diabetic Children.
Cureus
May 2024
Pediatric Endocrinology, Diabetology, and Metabolism Department, L'hôpital Femme Mère Enfant, Hospices Civils de Lyon, Claude Bernard University, Lyon, FRA.
Objective: This study aimed to describe the clinical, biochemical, therapeutic, and progressive characteristics of children with familial type 1 diabetes (T1D) compared to those with non-familial T1D. Compare within the first group, the phenotype of type 1 diabetics inherited from the father with those inherited from the mother.
Patients And Methods: We conducted a retrospective study lasting 10 years at the L'hôpital Femme Mère Enfant (Woman-Mother-Child Hospital) in Lyon, France.
Clinico-biological refinement of BCL11B-related disorder and identification of an episignature: A series of 20 unreported individuals.
Genet Med
January 2024
Montpellier University, Inserm UMR1183, Centre de Référence « Anomalies du Développement et Syndromes Malformatifs », ERN-ITHACA, Department of Clinical Genetics, University Hospital of Montpellier, Montpellier, France. Electronic address:
Purpose: BCL11B-related disorder (BCL11B-RD) arises from rare genetic variants within the BCL11B gene, resulting in a distinctive clinical spectrum encompassing syndromic neurodevelopmental disorder, with or without intellectual disability, associated with facial features and impaired immune function. This study presents an in-depth clinico-biological analysis of 20 newly reported individuals with BCL11B-RD, coupled with a characterization of genome-wide DNA methylation patterns of this genetic condition.
Methods: Through an international collaboration, clinical and molecular data from 20 individuals were systematically gathered, and a comparative analysis was conducted between this series and existing literature.
Immunologic constant of rejection as a predictive biomarker of immune checkpoint inhibitors efficacy in non-small cell lung cancer.
J Transl Med
September 2023
Multidisciplinary Oncology and Therapeutic Innovations Department, Aix Marseille Univ, APHM, INSERM, CNRS, CRCM, Hôpital Nord, Marseille, France.
Article Synopsis
- Anti-PD1/PDL1 immune checkpoint inhibitors have improved outcomes for advanced non-small cell lung cancer (NSCLC) patients, but response rates are low and potential for severe side effects makes biomarker identification necessary.
- Researchers analyzed gene expression in 44 NSCLC tumors treated with ICI, combining this with data from four public datasets to evaluate the Immunologic Constant of Rejection (ICR) as a predictor of clinical benefit.
- The study found that certain ICR classifications were significantly associated with higher rates of Durable Clinical Benefit (DCB) from treatment, suggesting that the 20-gene ICR signature could serve as an independent biomarker for predicting response to anti-PD1/PDL1 therapy.
Acute generalized exanthematous pustulosis: Clinico-biological profile and inducing drugs in 83 patients.
J Eur Acad Dermatol Venereol
June 2023
Department of Dermatology, AP-HP, Henri-Mondor Hospital, Creteil, France.
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