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Cardio-Lipotoxicity of Epicardial Adipose Tissue.
Biomolecules
November 2024
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Epicardial adipose tissue is a unique visceral adipose tissue depot that plays a crucial role in myocardial metabolism. Epicardial adipose tissue is a major source of energy and free fatty acids for the adjacent myocardium. However, under pathological conditions, epicardial fat can affect the heart through the excessive and abnormal influx of lipids.
View Article and Find Full Text PDFAssessing functional properties of diet protein hydrolysate and oil from fish waste on canine immune parameters, cardiac biomarkers, and fecal microbiota.
Front Vet Sci
November 2024
REQUIMTE, Network of Chemistry and Technology, LAQV, Laboratory for Green Chemistry, ICBAS, School of Medicine and Biomedical Sciences, University of Porto, Porto, Portugal.
Locally produced fish hydrolysate and oil from the agrifood sector comprises a sustainable solution both to the problem of fish waste disposal and to the petfood sector with potential benefits for the animal's health. This study evaluated the effects of the dietary replacement of mainly imported shrimp hydrolysate (5%) and salmon oil (3%; control diet) with locally produced fish hydrolysate (5%) and oil (3.2%) obtained from fish waste (experimental diet) on systemic inflammation markers, adipokines levels, cardiac function and fecal microbiota of adult dogs.
View Article and Find Full Text PDFThe association between adipokines dysregulation and the occurrence of atrial fibrillation and obese patients, is it relevant?
Arch Cardiol Mex
November 2024
Electrophysiology and Arrhythmias Service, 20 de Noviembre National Medical Center, Institute of Social Security and Services for State Workers, Mexico City, México.
Atrial fibrillation (AF) is the most common arrhythmia, affecting approximately 33.5 millions of people worldwide. Unfortunately, the prevalence of this arrhythmia will increase within the following two decades, resulting in a higher mortality rate and a higher economic burden for public health services.
View Article and Find Full Text PDFThe change of epicardial adipose tissue characteristics and vulnerability for atrial fibrillation upon drastic weight loss.
Adipocyte
December 2024
Departments of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Heart Centre, University of Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Background: Obesity increases the risk of atrial fibrillation (AF). We hypothesize that 'obese' epicardial adipose tissue (EAT) is, regardless of comorbidities, associated with markers of AF vulnerability.
Methods: Patients >40y of age undergoing bariatric surgery and using <2 antihypertensive drugs and no insulin were prospectively included.
Medicinal Plant Extracts against Cardiometabolic Risk Factors Associated with Obesity: Molecular Mechanisms and Therapeutic Targets.
Pharmaceuticals (Basel)
July 2024
Department of Molecular Biology and Genomics, Institute for Molecular Biology in Medicine and Gene Therapy, University Center of Health Sciences, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Obesity has increasingly become a worldwide epidemic, as demonstrated by epidemiological and clinical studies. Obesity may lead to the development of a broad spectrum of cardiovascular diseases (CVDs), such as coronary heart disease, hypertension, heart failure, cerebrovascular disease, atrial fibrillation, ventricular arrhythmias, and sudden cardiac death. In addition to hypertension, there are other cardiometabolic risk factors (CRFs) such as visceral adiposity, dyslipidemia, insulin resistance, diabetes, elevated levels of fibrinogen and C-reactive protein, and others, all of which increase the risk of CVD events.
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