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The decriminalization of illicit drugs in British Columbia: a national evaluation protocol.
BMC Public Health
October 2024
Institute for Mental Health Policy Research, Centre for Addiction and Mental Health (CAMH), 250 College St., Toronto, ON, M5T 1R8, Canada.
Background: On January 31st, 2023, the province of British Columbia (BC), Canada, was granted a federal exemption allowing adults (aged 18 +) to possess up to 2.5 g of select illicit drugs. The exemption will be in place for three years (2023-2026), marking the first formal decriminalization of illicit drug policy reform in Canada.
View Article and Find Full Text PDFMapping Lesion-Related Human Aggression to a Common Brain Network.
Biol Psychiatry
October 2024
Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Article Synopsis
- Aggression is a major issue in society, particularly among neuropsychiatric patients, but its underlying neural mechanisms and treatment options remain unclear.
- Researchers analyzed data from 182 Vietnam War veterans with head injuries to identify a specific brain network linked to aggression, finding a key hub in the right prefrontal cortex and other connected regions.
- The study suggests that targeting this aggression-associated brain circuit through neuromodulation methods, like deep brain stimulation, could be a potential therapeutic approach for managing aggression-related symptoms.
Smart Implantable Hydrogel for Large Segmental Bone Regeneration.
Adv Healthc Mater
December 2024
The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.
Large segmental bone defects often lead to nonunion and dysfunction, posing a significant challenge for clinicians. Inspired by the intrinsic bone defect repair logic of "vascularization and then osteogenesis", this study originally reports a smart implantable hydrogel (PDS-DC) with high mechanical properties, controllable scaffold degradation, and timing drug release that can proactively match different bone healing cycles to efficiently promote bone regeneration. The main scaffold of PDS-DC consists of polyacrylamide, polydopamine, and silk fibroin, which endows it with superior interfacial adhesion, structural toughness, and mechanical stiffness.
View Article and Find Full Text PDFThe new regulation of non-medical neurotechnologies in the European Union: overview and reflection.
J Law Biosci
September 2024
Utrecht University, Utrecht; Tilburg University, Department of Criminal Law, 5000 LE Tilburg, The Netherlands.
The regulation of neurotechnologies for non-medical purposes such as enhancement, gaming, or well-being is a topic of ongoing controversy. Without much attention, the European Union addressed it by two implementing regulations to the Medical Device Regulation (MDR) for non-invasive brain stimulation devices, passed in December 2022. This paper presents main aspect of these regulations and the conditions for placing non-medical neurodevices on the EU market, especially the risk threshold and the requirement for pre-market certification.
View Article and Find Full Text PDFThe Imperative of Regulation: The Co-creation of a Medical and Non-medical US Opioid Crisis.
Psychoactives
November 2023
Freudenthal Institute and Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, Utrecht, the Netherlands.
The ravaging COVID-19 pandemic has almost pushed into oblivion the fact that the United States is still struggling with an immense addiction crisis. Drug overdose deaths rose from 16,849 in 1999 to nearly 110000-of which an estimated 75,000 involved opioids-in 2022. On a yearly basis, the opioid casualty rate is higher than the combined number of victims of firearm violence and car accidents.
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