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| http://dx.doi.org/10.1016/j.anai.2020.05.005 | DOI Listing |
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Glucose Lowering through Weight management (GLoW): a randomised controlled trial of the clinical and cost effectiveness of a diabetes education and behavioural weight management programme vs a diabetes education programme in adults with a recent diagnosis of type 2 diabetes.
Diabetologia
January 2025
MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Aims/hypothesis: UK standard care for type 2 diabetes is structured diabetes education, with no effects on HbA, small, short-term effects on weight and low uptake. We evaluated whether remotely delivered tailored diabetes education combined with commercial behavioural weight management is cost-effective compared with current standard care in helping people with type 2 diabetes to lower their blood glucose, lose weight, achieve remission and improve cardiovascular risk factors.
Methods: We conducted a pragmatic, randomised, parallel two-group trial.
Methylmalonic acidaemia masquerading as a neurodegenerative disorder.
BMJ Case Rep
January 2025
Paediatrics, King George's Medical College, Lucknow, Uttar Pradesh, India.
We present the case of a toddler displaying neuroregression post-acute gastroenteritis, initially suggesting neurodegenerative disorders. Further investigations showed atypical results-neuroimaging was inconsistent with suspected disorders, while fundus evaluation, evoked potentials and nerve conduction velocity were normal. Specialised tests using gas chromatography mass spectrometry and tandem mass spectrometry identified methylmalonic acidaemia (MMA), implicating abnormal neurometabolism.
View Article and Find Full Text PDFThe implementation of a web-based diet quality screener as a self-management tool to improve the diet quality of adult patients with cardiovascular diseases.
Clin Nutr ESPEN
January 2025
Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands. Electronic address:
Background & Aims: Improving diet quality is a crucial aspect of cardiovascular disease (CVD) risk management. However, in clinical practice, there is limited time to evaluate diet quality and to provide dietary advice. Patients therefore mostly depend on self-management to address their diet quality.
View Article and Find Full Text PDFMetabolic Dysfunction-Associated Steatotic Liver Disease and the Cardiovascular System.
Trends Cardiovasc Med
January 2025
Department of Cardiology, Euroclinic Hospital, Athens, Greece; First Department of Cardiology, Athens University School of Medicine, Athens, Greece. Electronic address:
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed nonalcoholic fatty-liver disease, is an important and rising health issue with a link with atherosclerotic cardiovascular (CV) disease (CVD), affecting ∼25-30% of the adults in the general population; in patients with diabetes, its prevalence culminates to ∼70%; its evolutive form, nonalcoholic steatohepatitis, is estimated to be the main cause of liver transplantation in the future. MASLD is a multisystem disease that affects, besides the liver, extra-hepatic organs and regulatory pathways; it raises the risk of type 2 diabetes mellitus (T2D), CVD, and chronic kidney disease; the disease may also progress to hepatocellular carcinoma. Its diagnosis requires hepatic steatosis and at least one cardiometabolic risk factor and the exclusion of both significant alcohol consumption and other competing causes of chronic liver disease.
View Article and Find Full Text PDFPlant nutrient concentrations inform white-tailed deer diet limitations.
J Environ Manage
January 2025
School of Natural Resources, University of Tennessee, 401 Agriculture and Natural Resources Bldg., Knoxville, TN, 37996, USA.
Management of large herbivores often involves increasing availability of forages sufficient in nutrient density to allow animals to meet dietary demands. Nutritional carrying capacity (NCC) models commonly are used to compare plant communities and management strategies, but failure to use the most limiting nutrient could result in overestimating NCC. Moreover, the relationship between limiting nutrients often is not considered, which may influence the utility of NCC models based on a single nutrient, especially when herbivores must simultaneously meet multiple constraints.
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