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Wide field imaging biomarkers: A different perspective.
Taiwan J Ophthalmol
December 2024
Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Wide field retinal imaging has emerged as a transformative technology over the last few decades, revolutionizing our ability to visualize the intricate landscape of the retina. By capturing expansive retinal areas, these techniques offer a panoramic view going beyond traditional imaging methods. In this review, we explore the significance of retinal imaging-based biomarkers to help diagnose ocular and systemic conditions.
View Article and Find Full Text PDFUnveiling shadows: A data-driven insight on depression among Bangladeshi university students.
Heliyon
January 2025
Department of Computer Science and Engineering, BRAC University, Dhaka, Bangladesh.
Depression is more than just feeling sad. It is a severe and multifaceted mental health condition that impacts millions of individuals around the globe. Regrettably, it can even be more prevalent in university students of underdeveloped and developing countries like Bangladesh because of academic pressure, family and societal expectations, financial limitations, stigmatized social and cultural norms, unemployment concerns, lack of mental health awareness, etc.
View Article and Find Full Text PDFStroke Mimics at 30 Years: Where We Have Been, Where We Are Now, and Where We Are Going.
Stroke
January 2025
Department of Neurology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY.
Stroke mimics and chameleons remain a major challenge to the clinician and clinical investigator. Misdiagnosis of stroke can result in significant harm to our patients, as well as unnecessary financial costs to the health care systems internationally. The approach to stroke mimics and chameleons has evolved over time with the development of clinical scales and technology.
View Article and Find Full Text PDFBlarcamesine for the treatment of Early Alzheimer's Disease: Results from the ANAVEX2-73-AD-004 Phase IIB/III trial.
J Prev Alzheimers Dis
January 2025
Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA. Electronic address:
Background: There are no approved oral disease-modifying treatments for Alzheimer's disease (AD).
Objectives: The objective of this study was to assess efficacy and safety of blarcamesine (ANAVEX®2-73), an orally available small-molecule activator of the sigma-1 receptor (SIGMAR1) in early AD through restoration of cellular homeostasis including autophagy enhancement.
Design: ANAVEX2-73-AD-004 was a randomized, double-blind, placebo-controlled, 48-week Phase IIb/III trial.
Genetic Relationships and Molecular Signatures of Divergence in Traditional Landraces and Morphotypes of .
Plants (Basel)
December 2024
Institute of Biosciences and Bioresources, National Research Council, Via Amendola 165/A, 70126 Bari, Italy.
is a complex species incorporating a great variety of vegetable types, including cabbage, cauliflower, broccoli, kale, and others. Southern Italy, and especially the Puglia region, is rich in landraces. In this study, genotyping-by-sequencing (GBS) was applied to a germplasm panel of 82 samples, mostly landraces and some commercial varieties, belonging to various morphotypes of .
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