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Crowning the Kinetochore: The Fibrous Corona in Chromosome Segregation. | LitMetric

Crowning the Kinetochore: The Fibrous Corona in Chromosome Segregation.

Trends Cell Biol

Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4200-135 Porto, Portugal; Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, 4200-135 Porto, Portugal. Electronic address:

Published: August 2020

AI Article Synopsis

Article Abstract

The kinetochore is at the heart of chromosome segregation in mitosis and meiosis. Rather than a static linker complex for chromatin and spindle microtubules, it is highly dynamic in composition, size, and shape. While known for decades that it can expand and grow a fibrous meshwork known as the corona, it was until recently unclear what constitutes this 'crown' and what its relevance is for kinetochore function. Here, we highlight recent discoveries in fibrous corona biology, and place them in the context of the processes that orchestrate high-fidelity chromosome segregation.

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Source
http://dx.doi.org/10.1016/j.tcb.2020.04.006DOI Listing

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