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Sodium thiosulfate is effective in calcific uremic arteriolopathy complicating chronic hemodialysis.
Joint Bone Spine
January 2016
Service de rhumatologie, pôle appareil locomoteur, centre Viggo-Petersen, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France; UFR de médecine, université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France; Inserm, UMR-1132, hôpital Lariboisière, 75010 Paris, France. Electronic address:
Background: Calcific uremic arteriolopathy (CUA) or calciphylaxis is a severe complication of advanced chronic kidney disease (CKD) and dialysis. Few effective treatments are available and the mortality rate is high. We report 4 cases in which sodium thiosulfate therapy was rapidly effective.
View Article and Find Full Text PDFEndothelin-1 expression in scleroderma renal crisis.
Hum Pathol
January 2011
Université Paris Descartes, faculté de Médecine Paris Descartes, pôle de Médecine Interne, hôpital Cochin, Centre de référence pour les vascularites nécrosantes et la sclérodermie systémique, Assistance Publique-Hôpitaux de Paris (AP-HP), 75014 Paris, France.
The objective of the study was to investigate the role of endothelin-1 in the pathogenesis of scleroderma renal crisis in patients with systemic sclerosis. We used immunohistochemical analysis with anti-endothelin-1 and anti-von Willebrand factor antibodies in comparing kidney biopsies from patients with systemic sclerosis and scleroderma renal crisis (n = 14); from normal kidneys (n = 5); and from patients with typical hemolytic uremic syndrome and thrombotic microangiopathy (n = 5), antiphospholipid syndrome (n = 6), diabetic nephropathy (n = 5), minimal change disease with cyclosporine toxicity (n = 5), or nephroangiosclerosis (n = 5). Kidney biopsies from all systemic sclerosis patients presented specific lesions: glomerular lesions with thickened capillary walls (n = 6, 42.
View Article and Find Full Text PDF[Hemolytic uremic syndrome in adults].
Nephrol Ther
July 2010
Service des urgences néphrologiques et transplantation rénale, hôpital Tenon, 4, rue de la Chine, 75020 Paris, France.
Hemolytic uremic syndrome (HUS) is related to a renal thrombotic microangiopathy, inducing hypertension and acute renal failure (ARF). Its pathogenesis involves an activation/lesion of microvascular endothelial cells, mainly in the renal vasculature, secondary to bacterial toxins, drugs, or autoantibodies. An overactivation of the complement alternate pathway secondary to a heterozygote deficiency of regulatory proteins (factor H, factor I or MCP) or to an activating mutation of factor B or C3 can also result in HUS.
View Article and Find Full Text PDF[Chorea in hemodialysis: Is chorea just a neurological syndrome or is it related to uremia or dialysis?].
G Ital Nefrol
January 2003
Dipartimento dell'Emergenza e dei Trapianti d'Organo, Sezione di Nefrologia Universita' degli Studi di Bari, Italy.
Chronic renal failure and haemodialysis patients are prone to develop encephalopathy. The causes of encephalopathy are often unclear. Clinical signs of encephalopathy in the uraemic patient often overlap with several other affections causing neurological disorders.
View Article and Find Full Text PDF[Epidemiologic analysis of the incidence of new diabetic patients on dialysis as a basis for a clinical study].
Minerva Urol Nefrol
September 2000
Cattedra di Nefrologia, Università degli Studi, Torino.
Background: Aim of this study is to analyse the incidence of diabetic patients starting dialysis in Piedmont (Italy) during the period 1981-1996 and to evaluate, in a subgroup of patients, the causes of uremia (diabetic nephropathy or other), and the type and seriousness of comorbid factors, in order to define the clinical conditions and try to explain the causes incidence increase.
Methods: Data are taken from the RPDT (Regional Registry of Dialysis and Transplantation of Piedmont).
Results: Total incidence of new patients starting dialysis in this Region increased from 65 pmp in 1981-1982 to 116 pmp in 1995-1996 and the mean age increased from 55.
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