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-A Potential Source of Nutrients and Bioactive Components.
Plants (Basel)
December 2024
Department of Chemical Technology, Faculty of Chemistry, University of Plovdiv "Paisii Hilendarski", 24 Tzar Asen Street, 4000 Plovdiv, Bulgaria.
The Asteraceae family is a large plant family, with over 1600 genera and 25,000 species, most of which are generally herbaceous plants. This family's members are widely used in the human diet and medicine. One of the most popular representatives is L.
View Article and Find Full Text PDFModulation of -Induced Immune Response in Vaginal Epithelial Cells by Garcinoic Acid.
Microorganisms
November 2024
Department of Medicine and Surgery, Medical Microbiology Section, University of Perugia, 06123 Perugia, Italy.
Vulvovaginal candidiasis (VVC) is a prevalent women's infection characterized by excessive inflammation and damage of the vaginal epithelium that, in its recurrent form (RVVC), causes more than three symptomatic episodes per year, impacting nearly 8% of women globally. Current antifungal treatments alleviate symptoms but often fail to restore the inflammatory homeostasis of mucosal tissue and prevent recurrences. α-Tocopherol (α-TOH) and garcinoic acid (GA), a vitamin E metabolite, with immunomodulatory properties, were investigated for the first time in vaginal epithelial cells exposed to infection to assess their effects on inflammatory signaling parameters important to restore cellular homeostasis.
View Article and Find Full Text PDFMass Spectrometric Based Metabolomics of the Saudi Cultivar of Fenugreek ( L.): A Combined GC-MS, Antimicrobial and Computational Approach.
Pharmaceuticals (Basel)
December 2024
Department of Biology, College of Science, Qassim University, Buraydah 51452, Saudi Arabia.
In Saudi Arabia, numerous plant species with promising medicinal properties are cultivated, widely traded, and commonly utilized in traditional medicine, including fenugreek (). This study aimed to comprehensively assess the phytochemical composition and antimicrobial potential of the Saudi cultivar of fenugreek using an integrative approach combining in vitro and in silico methodologies. A comprehensive investigation was conducted on the ethanol extract of fenugreek seeds, assessing its antibacterial, antifungal, properties.
View Article and Find Full Text PDFVitamin E Improves Cellular and Structural Bone Histomorphometry in an Alcohol-Induced Osteoporosis Rat Model.
Pharmaceuticals (Basel)
December 2024
Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
: Alcohol-induced osteoporosis is a significant health concern, impairing bone formation and enhancing resorption, thereby weakening skeletal integrity. This study examines the effects of palm vitamin E on bone histomorphometry in a male rat model of alcohol-induced osteoporosis. : Three-month-old Sprague-Dawley rats were randomized into seven groups, with one baseline control group (BC) and six experimental groups undergoing a two-phase treatment.
View Article and Find Full Text PDFα-Tocopherol and Trolox as Effective Natural Additives for Polyurethane Foams: A DFT and Experimental Study.
Molecules
December 2024
Institute of Chemistry, University of Miskolc, 3515 Miskolc-Egyetemváros, Hungary.
In this work, α-tocopherol and trolox were studied as compounds that have high biological activity. α-Tocopherol is considered a food additive because the refining process of vegetable oils causes the depletion of this vitamin, and thus, its inclusion is required to keep them from oxidizing. Computational tools have determined the antioxidant activity of these additives.
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