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First isolation and characterization of from yak. | LitMetric
spp., facultative intracellular pathogens that can persistently colonize animal host cells and cause zoonosis, affect public health and safety. A strain was isolated from yak in Qinghai Province. To detect whether this isolate could cause an outbreak of brucellosis and to reveal its genetic characteristics, several typing and whole-genome sequencing methods were applied to identify its species and genetic characteristics. Phylogenetic analysis based on MLVA and whole-genome sequencing revealed the genetic characteristics of the isolated strain. The results showed that the isolated strain is a biovar 1 smooth strain, and this isolate was named QH05. The results of comparative genomics and MLVA showed that QH05 is not a vaccine strain. Comparison with other strains isolated from humans and animals indicated that QH05 may be linked to specific animal and human sources. In conclusion, QH05 does not belong to the epidemic species in China, and as the first isolation of from yak, this strain expands the host range of .
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