AI Article Synopsis
- Schizophrenia is a highly heritable mental disorder, and the study focuses on the association between a specific genetic variant (rs2734849 in the ANKK1 gene) and a common side effect of antipsychotics known as hyperprolactinemia (HPRL).
- Researchers genotyped 446 schizophrenia patients from Siberia to compare frequencies of the genetic variant between those experiencing HPRL and those who are not.
- Results indicated that patients with HPRL had a significantly higher frequency of the C allele of the rs2734849 polymorphism, suggesting a link between this genetic variation and the occurrence of HPRL in schizophrenia patients.
Article Abstract
Objective: Schizophrenia is a severe highly heritable mental disorder. Genetic polymorphisms of dopaminergic pathways are related to pathogenesis of drug response. Hyperprolactinemia (HPRL), a common adverse effect of antipsychotics, is attributed to blockade of dopamine D2 receptors. Ankyrin Repeat and Kinase Domain containing 1 (ANKK1) gene is closely related to Dopamine Receptor D2 type (DRD2) gene functioning. We examined whether the functional polymorphism rs2734849 in the ANKK1 gene is associated with antipsychotic-induced HPRL.
Methods: We recruited 446 patients with schizophrenia from among the Russian population of the Siberian region. The polymorphism rs2734849 in the ANKK1 gene was genotyped with The MassARRAY® Analyzer 4 by Agena Bioscience™, using the kit SEQUENOM Consumables iPLEXGold 384. Genotype and allele frequencies were compared between groups of schizophrenia patients with and without HPRL using the χ test.
Results: A comparison between schizophrenia patients with and without HPRL revealed significantly higher frequency of the C allele of the polymorphic variant rs2734849 in the ANKK1 gene in patients with HPRL as compared to the patients without it (χ = 3.70; p = .05; odds ratio [OR] = 1.30 [0.99-1.69]).
Conclusion: The functional polymorphism rs2734849 in the ANKK1 gene was associated with HPRL in patients with schizophrenia.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507142 | PMC |
| http://dx.doi.org/10.1002/hup.2737 | DOI Listing |
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