In this article, a high-yield method for the synthesis of sulfonyl 9-fluorenylidenes is described, which consists of a one-pot straightforward three-step synthetic route, including (i) CuBr-mediated α-bromination of -arylacetophenone, (ii) sequential nucleophilic substitution of the resulting α-bromo -arylacetophenone with sodium sulfinate (RSONa), and (iii) the CuBr-mediated intramolecular Friedel-Crafts cyclizative dehydration. A plausible mechanism is proposed and discussed. This protocol provides a highly effective regio- and stereoselective annulation via the formation of one carbon-carbon (C-C) bond and one carbon-sulfur (C-S) bond.
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